Linked Life Data

22028705

Source:http://linkedlifedata.com/resource/pubmed/id/22028705

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-10-26
pubmed:abstractText
Decrease of GABAergic transmission has been proposed to improve memory functions. Indeed, inverse agonists selective for ?5 GABA-A-benzodiazepine receptors (?5IA) have promnesiant activity. Interestingly, we have recently shown that ?5IA can rescue cognitive deficits in Ts65Dn mice, a Down syndrome mouse model with altered GABAergic transmission. Here, we studied the impact of chronic treatment with ?5IA on gene expression in the hippocampus of Ts65Dn and control euploid mice after being trained in the Morris water maze task. In euploid mice, chronic treatment with ?5IA increased IEGs expression, particularly of c-Fos and Arc genes. In Ts65Dn mice, deficits of IEGs activation were completely rescued after treatment with ?5IA. In addition, normalization of Sod1 overexpression in Ts65Dn mice after ?5IA treatment was observed. IEG expression regulation after ?5IA treatment following behavioral stimulation could be a contributing factor for both the general promnesiant activity of ?5IA and its rescuing effect in Ts65Dn mice alongside signaling cascades that are critical for memory consolidation and cognition.
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:issn
1687-6342
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2011
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153218
pubmed:year
2011
pubmed:articleTitle
Chronic Treatment with a Promnesiant GABA-A ?5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model.
pubmed:affiliation
Centre de Recherche de l'Institut du Cerveau et de Moelle Epinière, INSERM UMRS 975, CNRS UMR7225, UPMC, 75013 Paris, France.
pubmed:publicationType
Journal Article