Linked Life Data

2202379

Source:http://linkedlifedata.com/resource/pubmed/id/2202379

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-9-28
pubmed:abstractText
Expression of the myc family of cellular proto-oncogenes is critical for determining the proliferative, differentiative, and oncogenic potential of a wide variety of cell types. Despite a large body of genetic and biochemical data indicating that myc proteins are located in the nucleus and can bind to nucleic acids, the mechanism by which these proteins exert their effects remains a mystery. The recent observation that myc proteins contain two structural domains previously identified in transcription factors and differentiation factors, the leucine zipper domain and the helix-loop-helix motif, supports the notion that these proteins directly regulate gene expression. In this review we consider the possible significance of these domains to myc function.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1042-2196
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-75
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Are myc proteins transcription factors?
pubmed:affiliation
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't