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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1990-9-24
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pubmed:abstractText |
A cell line, ATDC5, isolated from a differentiating culture of AT805 teratocarcinoma expressed a fibroblastic cell phenotype in a growing phase. With the addition of 10 micrograms/ml insulin to the medium, cells continued to grow even in a postconfluent phase, formed cartilage nodule-like cell aggregates, were stained with Alcian blue and produced cartilage-specific proteoglycan and type II collagen, typical marker molecules for chondrogenesis. Since ATDC5 cells also differentiated into unidentifiable pigmented cells, they are apparently composed of undetermined cells. ATDC5, therefore, provides a good model system with which to understand chondrogenic differentiation.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
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pubmed:issn |
0922-3371
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-16
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2201423-Animals,
pubmed-meshheading:2201423-Cartilage,
pubmed-meshheading:2201423-Cell Differentiation,
pubmed-meshheading:2201423-Cell Line,
pubmed-meshheading:2201423-Collagen,
pubmed-meshheading:2201423-Insulin,
pubmed-meshheading:2201423-Mice,
pubmed-meshheading:2201423-Proteoglycans,
pubmed-meshheading:2201423-Teratoma
|
pubmed:year |
1990
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pubmed:articleTitle |
A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells.
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pubmed:affiliation |
Laboratory of Molecular Oncology, Tsukuba Life Science Center, Ibaraki, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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