Linked Life Data

21995022

Source:http://linkedlifedata.com/resource/pubmed/id/21995022

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 2
pubmed:dateCreated
2011-10-14
pubmed:abstractText
White matter fiber tractography plays a key role in the in vivo understanding of brain circuitry. For tract-based comparison of a population of images, a common approach is to first generate an atlas by averaging, after spatial normalization, all images in the population, and then perform tractography using the constructed atlas. The reconstructed fiber trajectories form a common geometry onto which diffusion properties of each individual subject can be projected based on the corresponding locations in the subject native space. However, in the case of High Angular Resolution Diffusion Imaging (HARDI), where modeling fiber crossings is an important goal, the above-mentioned averaging method for generating an atlas results in significant error in the estimation of local fiber orientations and causes a major loss of fiber crossings. These limitatitons have significant impact on the accuracy of the reconstructed fiber trajectories and jeopardize subsequent tract-based analysis. As a remedy, we present in this paper a more effective means of performing tractography at a population level. Our method entails determining a bipolar Watson distribution at each voxel location based on information given by all images in the population, giving us not only the local principal orientations of the fiber pathways, but also confidence levels of how reliable these orientations are across subjects. The distribution field is then fed as an input to a probabilistic tractography framework for reconstructing a set of fiber trajectories that are consistent across all images in the population. We observe that the proposed method, called PoPTRACT, results in significantly better preservation of fiber crossings, and hence yields better trajectory reconstruction in the atlas space.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:author
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-40
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Reconstruction of fiber trajectories via population-based estimation of local orientations.
pubmed:affiliation
BRIC, Department of Radiology, University of North Carolina at Chapel Hill, NC, USA. ptyap@med.unc.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural