Linked Life Data

2198580

Source:http://linkedlifedata.com/resource/pubmed/id/2198580

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1990-9-5
pubmed:abstractText
HIV-1, the primary etiologic agent of AIDS, is a non-transforming human retrovirus which shares many physical and functional characteristics with viruses from the lentivirus family. One of these characteristics is that HIV-1 infection has profound cytopathic effects on host cells. Studies by the membrane fluorescence dequenching (DQ) method using HIV-1 virions labeled with octadecylrhodamine B-chloride (R-18) have shown that HIV-1 enters host cells by a process of fusion between viral envelope and target cell plasma membrane. The parameters of HIV-1-cell fusion are similar to those established for paramyxoviruses and other enveloped fusogenic viruses. HIV-1-cell fusion requires the presence of surface CD4 receptors on human T cell and monocytes, but not on human glial and neuronal cells. It is proposed that cell surface effects of HIV-1 due to the interaction between HIV-1 fusion glycoproteins and membrane receptors are major contributors to the cytopathic and pathogenic function of this virus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-7742
pubmed:author
pubmed:issnType
Print
pubmed:volume
343
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-98
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Fusion of human immunodeficiency virus type 1 (HIV-1) with human cells as measured by membrane fluorescence dequenching (DQ) method; roles of HIV-1-cell fusion in AIDS pathogenesis.
pubmed:affiliation
Molecular Virology Laboratory, St. Luke's/Roosevelt Hospital Center, New York, N.Y.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Review