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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1990-9-4
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pubmed:abstractText |
Long-term effects of bezafibrate on in vivo production of VLDL-triglyceride were studied in the rat. Bezafibrate given at a daily dose of 30 mg/kg body weight for 14 days produced a decrease not only in triglyceride by 51% but in cholesterol by 28% and phospholipid by 18%. Despite a marked reduction in plasma triglyceride concentrations, there was no significant change in the rate of VLDL-triglyceride secretion from the liver into the circulation between bezafibrate-treated and control animals (1113 +/- 58 and 1234 +/- 63 micrograms/min, respectively). In addition, bezafibrate produced no change in lipid composition in VLDL. These results suggest that bezafibrate enhances triglyceride removal from the circulation, which leads to reduction in plasma triglyceride.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bezafibrate,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Detergents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, VLDL,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/tyloxapol,
http://linkedlifedata.com/resource/pubmed/chemical/very low density lipoprotein...
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pubmed:status |
MEDLINE
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pubmed:issn |
0168-8227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2198155-Animals,
pubmed-meshheading:2198155-Bezafibrate,
pubmed-meshheading:2198155-Blood Glucose,
pubmed-meshheading:2198155-Cholesterol,
pubmed-meshheading:2198155-Cholesterol, HDL,
pubmed-meshheading:2198155-Detergents,
pubmed-meshheading:2198155-Insulin,
pubmed-meshheading:2198155-Lipoproteins, VLDL,
pubmed-meshheading:2198155-Liver,
pubmed-meshheading:2198155-Male,
pubmed-meshheading:2198155-Phospholipids,
pubmed-meshheading:2198155-Polyethylene Glycols,
pubmed-meshheading:2198155-Rats,
pubmed-meshheading:2198155-Rats, Inbred Strains,
pubmed-meshheading:2198155-Reference Values,
pubmed-meshheading:2198155-Triglycerides
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pubmed:articleTitle |
Long-term effects of bezafibrate on in vivo VLDL-triglyceride production in the rat.
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pubmed:affiliation |
Department of Medicine, Hyogo Medical Center for Adults, Akashi, Japan.
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pubmed:publicationType |
Journal Article
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