Linked Life Data

2197241

Source:http://linkedlifedata.com/resource/pubmed/id/2197241

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-8-30
pubmed:abstractText
The expression of epidermal growth factor receptor (EGFR) was studied in the normal and inflamed cervix uteri, and the results were compared with estrogen receptor (ER) expression. The study was performed on fresh frozen specimens from 18 cases by means of immunohistochemistry, with application of EGFR1 antibody and an ER-ICA kit (Abbott, Wiesbaden, F.R.G.). The EGFR was expressed by the basal and parabasal layers of ectocervical and metaplastic epithelium and by reserve cells. No cyclic fluctuations in EGFR expression were noted. The glandular epithelium did not express EGFR. Some glands stained positive in the region of the basement membrane. Staining was not diminished in inflammatory foci, in contrast to ER expression, which was trace or absent. This was observed in both normal and dysplastic squamous epithelium. It may be assumed that the change of the normal relationship between ERs and EGFRs influences the process of proliferation and maturation of the squamous epithelium and may play a role in its disturbances.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0277-1691
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
263-71
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Epidermal growth factor receptor expression in the normal and inflamed cervix uteri: a comparison with estrogen receptor expression.
pubmed:affiliation
Department of Pathomorphology, Medical School of Warsaw, Poland.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't