Linked Life Data

2196819

Source:http://linkedlifedata.com/resource/pubmed/id/2196819

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Pt 1
pubmed:dateCreated
1990-8-23
pubmed:abstractText
Opiate peptides administered on one side of the blood-brain barrier can exert powerful effects on processes occurring on the other side. There is evidence for direct passage of opiate peptides and their analogues across this barrier. Beta-Endorphin can enter the cerebrospinal fluid after systemic administration, but its entry into brain tissue has been more difficult to demonstrate, even though analogues enter at a modest rate. Enkephalins enter and exit the central nervous system as intact molecules by a combination of saturable and nonsaturable mechanisms. A family of transport systems may exist with varying affinities for the opiate enkephalins, antiopiates like tyrosine melanocyte-stimulating hormone inhibitory factor 1 (Tyr-MIF-1), and related peptides. The major system transporting these peptides, termed Peptide transport system 1, can be influenced by several factors with entry and exit rates affected by aging, drugs, amino acids, monoamines, aluminum, stress, and ethanol addiction and withdrawal. The homeostatic role of the blood-brain barrier thus extends to the regulation of the bidirectional transport of informational peptides such as the opiates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
259
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
E1-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Peptide transport systems for opiates across the blood-brain barrier.
pubmed:affiliation
Veterans Administration Medical Center, New Orleans, Louisiana.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review