21951283

Source:http://linkedlifedata.com/resource/pubmed/id/21951283

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006142, umls-concept:C1061928, umls-concept:C1122918, umls-concept:C1956422, umls-concept:C1999216
pubmed:issue	5
pubmed:dateCreated	2011-9-28
pubmed:abstractText	Cancer stem cells make up a subpopulation of cells within tumours that drive tumour initiation, growth and recurrence. They are resistant to many current types of cancer treatment, causing failure of such therapeutic approaches, including chemotherapy and radiotherapy. In the study described here, anti-proliferative effects of 3-O-methylfunicone (OMF), a metabolite from Penicillium pinophilum, were investigated on human breast cancer MCF-7 cells and cancer stem cells selected as mammospheres derived from MCF-7s.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9105195
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/3-O-methylfunicone, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/BIRC5 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Apoptosis Proteins, http://linkedlifedata.com/resource/pubmed/chemical/NANOG protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Pyrones, http://linkedlifedata.com/resource/pubmed/chemical/TERT protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Telomerase
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	1365-2184
pubmed:author	pubmed-author:BuomminoEE, pubmed-author:CiavattaM LML, pubmed-author:De FilippisAA, pubmed-author:NicolettiRR, pubmed-author:PirozziGG, pubmed-author:SilvestriFF, pubmed-author:TirinoVV, pubmed-author:TufanoM AMA
pubmed:copyrightInfo	© 2011 Blackwell Publishing Ltd.
pubmed:issnType	Electronic
pubmed:volume	44
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	401-9
pubmed:meshHeading	pubmed-meshheading:21951283-Antineoplastic Agents, pubmed-meshheading:21951283-Apoptosis, pubmed-meshheading:21951283-Base Sequence, pubmed-meshheading:21951283-Breast Neoplasms, pubmed-meshheading:21951283-Cell Line, Tumor, pubmed-meshheading:21951283-Cell Proliferation, pubmed-meshheading:21951283-DNA Primers, pubmed-meshheading:21951283-Female, pubmed-meshheading:21951283-Gene Expression, pubmed-meshheading:21951283-Homeodomain Proteins, pubmed-meshheading:21951283-Humans, pubmed-meshheading:21951283-Inhibitor of Apoptosis Proteins, pubmed-meshheading:21951283-Neoplastic Stem Cells, pubmed-meshheading:21951283-Penicillium, pubmed-meshheading:21951283-Polymerase Chain Reaction, pubmed-meshheading:21951283-Pyrones, pubmed-meshheading:21951283-Spheroids, Cellular, pubmed-meshheading:21951283-Telomerase, pubmed-meshheading:21951283-Tumor Stem Cell Assay
pubmed:year	2011
pubmed:articleTitle	3-O-methylfunicone, from Penicillium pinophilum, is a selective inhibitor of breast cancer stem cells.
pubmed:affiliation	Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, SUN, Naples, Italy.
pubmed:publicationType	Journal Article