Linked Life Data

21941552

Source:http://linkedlifedata.com/resource/pubmed/id/21941552

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-9-23
pubmed:abstractText
In the present pilot study (56 patients), some red blood cell parameters in samples from patients with metabolic syndrome and subclinical atherosclerosis, but without any sign of coronary artery disease, have been analyzed. The main goal of this work was to determine, in this preclinical state, new peripheral gender-associated bioindicators of possible diagnostic or prognostic value. In particular, three different "indicators" of red blood cell injury and aging have been evaluated: glycophorin A, CD47, and phosphatidylserine externalization. Interestingly, all these determinants appeared significantly modified and displayed gender differences. These findings could provide novel and useful hints in the research for gender-based real-time bioindicators in the progression of metabolic syndrome towards coronary artery disease. Further, more extensive studies are, however, necessary in order to validate these findings.
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:issn
1687-8884
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2011
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
204157
pubmed:year
2011
pubmed:articleTitle
The red blood cell as a gender-associated biomarker in metabolic syndrome: a pilot study.
pubmed:affiliation
Section of Cell Degeneration and Gender Medicine, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
pubmed:publicationType
Journal Article