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pubmed-article:2193528pubmed:abstractTextThe effect of cachexia on insulin secretion was examined in adult male rats. Isolated islets of Langerhans from Walker 256 tumor-bearing rats secreted less insulin by glucose stimuli as compared with the control group; this was accompanied by significant change in 45Ca2+ outflow rate. Reduced insulin secretion to glucose stimuli in tumor-bearing rats probably led to low insulinemia (one-third). These findings indicate that reduced insulin secretion is probably an important factor for the development of cachexia in Walker 256 tumor-bearing rats.lld:pubmed
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pubmed-article:2193528pubmed:articleTitleInsulin secretion in Walker 256 tumor cachexia.lld:pubmed
pubmed-article:2193528pubmed:affiliationDepartment of Physiology and Biophysics, São Paulo University, Brazil.lld:pubmed
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