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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6 Pt 1
|
| pubmed:dateCreated |
1990-8-2
|
| pubmed:abstractText |
The effect of cachexia on insulin secretion was examined in adult male rats. Isolated islets of Langerhans from Walker 256 tumor-bearing rats secreted less insulin by glucose stimuli as compared with the control group; this was accompanied by significant change in 45Ca2+ outflow rate. Reduced insulin secretion to glucose stimuli in tumor-bearing rats probably led to low insulinemia (one-third). These findings indicate that reduced insulin secretion is probably an important factor for the development of cachexia in Walker 256 tumor-bearing rats.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
258
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
E1033-6
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2193528-Animals,
pubmed-meshheading:2193528-Cachexia,
pubmed-meshheading:2193528-Calcium,
pubmed-meshheading:2193528-Carcinoma 256, Walker,
pubmed-meshheading:2193528-Glucose,
pubmed-meshheading:2193528-Insulin,
pubmed-meshheading:2193528-Islets of Langerhans,
pubmed-meshheading:2193528-Kinetics,
pubmed-meshheading:2193528-Male,
pubmed-meshheading:2193528-Rats,
pubmed-meshheading:2193528-Rats, Inbred Strains,
pubmed-meshheading:2193528-Reference Values
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Insulin secretion in Walker 256 tumor cachexia.
|
| pubmed:affiliation |
Department of Physiology and Biophysics, São Paulo University, Brazil.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|