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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1990-8-2
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pubmed:databankReference |
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pubmed:abstractText |
The sixth member of the fibroblast growth factor gene family was cloned and analysed in the mouse. It is composed of three coding exons and encodes a putative growth protein of 198 amino acids, possessing a potential signal peptide, and presenting 79% and 93.5% sequence similarity with the mouse Hst/K-fgf and human FGF-6 genes products, respectively. The murine Fgf-6 gene is located in a region distinct from the Int-41 locus and belongs to a linkage group conserved between chromosome 12 in man and chromosome 6 in mouse. It presents an intrinsic oncogenic capacity since it is able to transform cultured fibroblasts. Fgf-6 mRNA levels are developmentally regulated with a peak of expression in the developing fetus at day 15.5 of gestation, moderate levels during late gestation and in the neonate. In the adult, Fgf-6 mRNA can be detected in testis, heart and skeletal muscle.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0950-9232
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
823-31
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2193291-Animals,
pubmed-meshheading:2193291-Base Sequence,
pubmed-meshheading:2193291-Cell Transformation, Neoplastic,
pubmed-meshheading:2193291-Chromosome Mapping,
pubmed-meshheading:2193291-Cloning, Molecular,
pubmed-meshheading:2193291-Embryo, Mammalian,
pubmed-meshheading:2193291-Fibroblast Growth Factor 6,
pubmed-meshheading:2193291-Fibroblast Growth Factors,
pubmed-meshheading:2193291-Fibroblasts,
pubmed-meshheading:2193291-Gene Expression,
pubmed-meshheading:2193291-Humans,
pubmed-meshheading:2193291-Mice,
pubmed-meshheading:2193291-Mice, Inbred C3H,
pubmed-meshheading:2193291-Molecular Sequence Data,
pubmed-meshheading:2193291-Molecular Structure,
pubmed-meshheading:2193291-Muscles,
pubmed-meshheading:2193291-Myocardium,
pubmed-meshheading:2193291-Proto-Oncogene Proteins
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pubmed:year |
1990
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pubmed:articleTitle |
Structure, chromosome mapping and expression of the murine Fgf-6 gene.
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pubmed:affiliation |
U .119 INSERM, Marseille, France.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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