Linked Life Data

2192633

Source:http://linkedlifedata.com/resource/pubmed/id/2192633

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1990-7-24
pubmed:abstractText
The major findings of the present study can be summarized as follows: 1. The newly developed assay for quantitative determination of ras protooncogene expression which utilizes affinity labeling of ras p21 with [alpha-32P]GTP can effectively demonstrate the presence of ras protooncogene expression in explant cultures of human mammary tissues. 2. The prototype chemical carcinogens NMU and BP induce amplified expression of ras protooncogene in benign (noninvolved) human mammary TDLU. 3. The specific enhancement of ras expression by BP in TDLU (target tissue) but not in MF (nontarget tissue) for tumorigenesis indicates that the constitutive levels of ras protooncogene in the target tissue are responsive to carcinogenic insult. 4. The relative extent of ras protooncogene expression may constitute a sensitive marker for target tissue susceptibility to chemical carcinogenesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
586
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
230-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Cellular ras protooncogene expression in human mammary explant cultures. A potential marker for chemical carcinogenesis.
pubmed:affiliation
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't