Linked Life Data

21916204

Source:http://linkedlifedata.com/resource/pubmed/id/21916204

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-9-15
pubmed:abstractText
The state of dynamic equilibrium between the host micro-organisms, it settled, and the environment called "eubiosis" in which human health is at an optimum level. The development of the gastrointestinal tract requiring surgical intervention was determined not only by the degree of pathological process activity, endotoxemia level dysbiotic bowel disturbances, but also disturbances in the patient's immune system. The aim of our study was to examine the influence of gut microbiota and endotoxemia on the development of comorbidity and functional status of the liver in patients after hemicolectomy. Were studied a total of 365 patients after undergoing surgery hemicolectomy (right-and left-handed). Results: violations in microbiocenosis intestine, which is most frequently observed in patients after left-sided hemicolectomy, leads to the development of endotoxemia, its toxic effects on the liver, were realized in the development of liver steatosis and steatohepatitis. Thus, the left-sided hemicolectomy increases the risk of steatohepatitis in the late period, which may affect the core functions of the liver and the development of other metabolic disorders. Hyperendotoxemia that was developed in patients as a result of violations of microbiota after left-sided hemicolectomy, increases the risk of developing diseases pancreat-duodenal zone and cardiovascular changes. Certainly, the pathogenesis of these diseases was not determined by left-sided hemicolectomy, but her conduct contributed to the development and progression of these diseases.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1682-8658
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
60-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
[Role of intestinal microbiocenosis and endotoxemia in the development of accompanying diseases and functional status of liver in patients after hemicolectomy].
pubmed:publicationType
Journal Article, In Vitro, English Abstract