21915187

Source:http://linkedlifedata.com/resource/pubmed/id/21915187

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0002771, umls-concept:C0003209, umls-concept:C0441655, umls-concept:C0599956, umls-concept:C1483745, umls-concept:C1515655, umls-concept:C1533691, umls-concept:C1555707, umls-concept:C1705851, umls-concept:C2752151, umls-concept:C2828366
pubmed:dateCreated	2011-9-14
pubmed:abstractText	Plectranthus amboinicus (Lour.) Spreng. is a native Labiatae plant of Taiwan. The plants are commonly used in Chinese folk medicine for the treatment of cough, fever, sore throats, mumps, and mosquito bite. The aim of this study was to investigate the analgesic and antiinflammatory properties of the aqueous extract from Plectranthus amboinicus (PA) in vivo and in vitro. PA inhibited pain induced by acetic acid and formalin, and inflammation induced by carrageenan. The anti-inflammatory effect of PA was related to modulating antioxidant enzymes' activities in the liver and decreasing the Malondialdehyde (MDA) level and the production of tumor necrosis factor alpha (TNF-?), and cyclooxygenase2 (COX-2) in edema-paw tissue in mice. In vitro studies show that PA inhibited the proinflammatory mediators in RAW 264.7 cells stimulated with lipopolysaccharide (LPS). PA blocked the degradation of I?B-? and nuclear translocation of NF-?B p65 subunit. Finally, the amount of carvacrol in the aqueous extract of PA was 1.88?mg/g extract. Our findings suggest that PA has analgesic and anti-inflammatory activities. These effects were mediated by inhibiting the proinflammatory mediators through blocking NF-?B activation. Meanwhile, the effects observed in this study provide evidence for folkloric uses of Plectranthus amboinicus (Lour.) Spreng. in relieving pain and inflammation.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101215021
pubmed:status	PubMed-not-MEDLINE
pubmed:issn	1741-4288
pubmed:author	pubmed-author:ChenChiu-YuanCY, pubmed-author:ChenYa-WenYW, pubmed-author:ChiuChuan-SungCS, pubmed-author:ChiuYung-JiaYJ, pubmed-author:HuangTai-HungTH, pubmed-author:LuTsung-ChunTC, pubmed-author:PengWen-HuangWH
pubmed:issnType	Electronic
pubmed:volume	2012
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	508137
pubmed:year	2012
pubmed:articleTitle	Analgesic and Antiinflammatory Activities of the Aqueous Extract from Plectranthus amboinicus (Lour.) Spreng. Both In Vitro and In Vivo.
pubmed:affiliation	School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, no. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.
pubmed:publicationType	Journal Article