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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11 Suppl
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pubmed:dateCreated |
2011-9-13
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pubmed:abstractText |
Under normoxic conditions, hypoxia-inducible factor (HIF)-1? is rapidly degraded by 2 hydroxylases: prolyl hydroxylase (PHD) and factor-inhibiting HIF-1 (FIH). Because HIF-1? mediates the cardioprotective response to ischemic injury, its upregulation may be an effective therapeutic option for ischemic heart failure.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:GiacciaAmato JAJ,
pubmed-author:GongYongquanY,
pubmed-author:HuShijunS,
pubmed-author:HuangMeiM,
pubmed-author:JiaFangjunF,
pubmed-author:KayMark AMA,
pubmed-author:NagDivyaD,
pubmed-author:NguyenPatriciaP,
pubmed-author:RobbinsRobert CRC,
pubmed-author:WangLiL,
pubmed-author:WuJoseph CJC,
pubmed-author:de AlmeidaPatricia EPE
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S46-54
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pubmed:meshHeading |
pubmed-meshheading:21911818-Animals,
pubmed-meshheading:21911818-Apoptosis,
pubmed-meshheading:21911818-Embryonic Stem Cells,
pubmed-meshheading:21911818-Female,
pubmed-meshheading:21911818-Gene Knockdown Techniques,
pubmed-meshheading:21911818-Gene Therapy,
pubmed-meshheading:21911818-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:21911818-Mice,
pubmed-meshheading:21911818-Mice, Inbred Strains,
pubmed-meshheading:21911818-Mixed Function Oxygenases,
pubmed-meshheading:21911818-Models, Animal,
pubmed-meshheading:21911818-Myoblasts, Cardiac,
pubmed-meshheading:21911818-Myocardial Infarction,
pubmed-meshheading:21911818-Myocardium,
pubmed-meshheading:21911818-Myocytes, Cardiac,
pubmed-meshheading:21911818-Neovascularization, Physiologic,
pubmed-meshheading:21911818-Procollagen-Proline Dioxygenase,
pubmed-meshheading:21911818-Stem Cell Transplantation,
pubmed-meshheading:21911818-Treatment Outcome
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pubmed:year |
2011
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pubmed:articleTitle |
Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction.
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pubmed:affiliation |
Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305-5454, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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