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rdf:type |
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lifeskim:mentions |
umls-concept:C0021308,
umls-concept:C0026032,
umls-concept:C0205147,
umls-concept:C0331858,
umls-concept:C0597304,
umls-concept:C0599894,
umls-concept:C1521840,
umls-concept:C1533685,
umls-concept:C1704259,
umls-concept:C1704640,
umls-concept:C1705987,
umls-concept:C1706515
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pubmed:issue |
11 Suppl
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pubmed:dateCreated |
2011-9-13
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pubmed:abstractText |
Although localized delivery of biocomposite materials, such as calcium hydroxyapatite (CHAM), have been demonstrated to potentially attenuate adverse left ventricular (LV) remodeling after myocardial infarction (MI), the underlying biological mechanisms for this effect remain unclear. This study tested the hypothesis that targeted CHAM injections would alter proteolytic pathways (matrix metalloproteinases [MMPs] and tissue inhibitors of MMPs [TIMPs]) and would be associated with parameters of post-MI LV remodeling.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:BakerNathaniel LNL,
pubmed-author:DixonJennifer AJA,
pubmed-author:GormanJoseph HJH3rd,
pubmed-author:GormanRobert CRC,
pubmed-author:HamamotoHirotsuguH,
pubmed-author:MeyerEvan CEC,
pubmed-author:MoritaMasatoM,
pubmed-author:MukherjeeRupakR,
pubmed-author:RyanLiam PLP,
pubmed-author:SpinaleFrancis GFG,
pubmed-author:StroudRobert ERE
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S35-45
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pubmed:meshHeading |
pubmed-meshheading:21911817-Animals,
pubmed-meshheading:21911817-Collagen,
pubmed-meshheading:21911817-Durapatite,
pubmed-meshheading:21911817-Extracellular Matrix,
pubmed-meshheading:21911817-Injections,
pubmed-meshheading:21911817-Male,
pubmed-meshheading:21911817-Matrix Metalloproteinase 13,
pubmed-meshheading:21911817-Matrix Metalloproteinases,
pubmed-meshheading:21911817-Microspheres,
pubmed-meshheading:21911817-Models, Animal,
pubmed-meshheading:21911817-Myocardial Infarction,
pubmed-meshheading:21911817-Sheep,
pubmed-meshheading:21911817-Signal Transduction,
pubmed-meshheading:21911817-Tissue Inhibitor of Metalloproteinases,
pubmed-meshheading:21911817-Treatment Outcome,
pubmed-meshheading:21911817-Ventricular Remodeling
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pubmed:year |
2011
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pubmed:articleTitle |
Targeted regional injection of biocomposite microspheres alters post-myocardial infarction remodeling and matrix proteolytic pathways.
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pubmed:affiliation |
Cardiothoracic Surgery, Medical University of SouthCarolina and Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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