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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
36
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pubmed:dateCreated |
2011-9-8
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pubmed:abstractText |
Recurrent seizure activity has been shown to induce a variety of permanent structural changes in the brain. Matrix metalloproteinases (MMPs) function to promote neuronal plasticity, primarily through cleavage of extracellular matrix proteins. Here, we investigated the role of MMP-9 in the development of pentylenetetrazole (PTZ)-induced kindled seizure in mice. Repeated treatment with PTZ (40 mg/kg) produced kindled seizure, which was accompanied by enhanced MMP-9 activity and expression in the hippocampus. No change in MMP-9 activity was observed in the hippocampi of mice with generalized tonic seizure following single administration of PTZ (60 mg/kg). MMP-9 colocalized with the neuronal marker NeuN and the glial marker GFAP in the dentate gyrus of the kindled mouse hippocampus. Coadministration of diazepam or MK-801 with PTZ inhibited the development of kindling and the increased MMP-9 levels in the hippocampus. Marked suppression of kindled seizure progression in response to repeated PTZ treatment was observed in MMP-9((-/-)) mice compared with wild-type mice, an observation that was accompanied by decreased hippocampal levels of mature brain-derived neurotrophic factor. Microinjecting the BDNF scavenger TrkB-Fc into the right ventricle before each PTZ treatment significantly suppressed the development of kindling in wild-type mice, whereas no effect was observed in MMP-9((-/-)) mice. On the other hand, bilateral injections of pro-BDNF into the hippocampal dentate gyrus significantly enhanced kindling in wild-type mice but not MMP-9((-/-)) mice. These findings suggest that MMP-9 is involved in the progression of behavioral phenotypes in kindled mice because of conversion of pro-BDNF to mature BDNF in the hippocampus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Brain-Derived Neurotrophic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Convulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Diazepam,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Pentylenetetrazole,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, trkB,
http://linkedlifedata.com/resource/pubmed/chemical/brain-derived neurotrophic factor...,
http://linkedlifedata.com/resource/pubmed/chemical/tropomyosin-related kinase-B, bovine
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1529-2401
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pubmed:author |
pubmed-author:IbiDaisukeD,
pubmed-author:ItoharaShigeyoshiS,
pubmed-author:KameiHiroyukiH,
pubmed-author:KoikeHiroyukiH,
pubmed-author:MizoguchiHiroyukiH,
pubmed-author:NabeshimaToshitakaT,
pubmed-author:NakadeJunyaJ,
pubmed-author:SatoJunJ,
pubmed-author:SawadaMakotoM,
pubmed-author:SomeyaEiichiE,
pubmed-author:TachibanaMasakiM,
pubmed-author:TakumaKazuhiroK,
pubmed-author:YamadaKiyofumiK
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pubmed:issnType |
Electronic
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pubmed:day |
7
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12963-71
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pubmed:meshHeading |
pubmed-meshheading:21900575-Animals,
pubmed-meshheading:21900575-Anticonvulsants,
pubmed-meshheading:21900575-Blotting, Western,
pubmed-meshheading:21900575-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:21900575-Convulsants,
pubmed-meshheading:21900575-Diazepam,
pubmed-meshheading:21900575-Dizocilpine Maleate,
pubmed-meshheading:21900575-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:21900575-Fear,
pubmed-meshheading:21900575-Hippocampus,
pubmed-meshheading:21900575-Kindling, Neurologic,
pubmed-meshheading:21900575-Male,
pubmed-meshheading:21900575-Matrix Metalloproteinase 9,
pubmed-meshheading:21900575-Memory,
pubmed-meshheading:21900575-Mice,
pubmed-meshheading:21900575-Mice, Inbred ICR,
pubmed-meshheading:21900575-Mice, Knockout,
pubmed-meshheading:21900575-Microinjections,
pubmed-meshheading:21900575-Nerve Tissue Proteins,
pubmed-meshheading:21900575-Neuroprotective Agents,
pubmed-meshheading:21900575-Pentylenetetrazole,
pubmed-meshheading:21900575-Protein Kinases,
pubmed-meshheading:21900575-Protein Precursors,
pubmed-meshheading:21900575-RNA, Messenger,
pubmed-meshheading:21900575-Receptor, trkB,
pubmed-meshheading:21900575-Seizures
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pubmed:year |
2011
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pubmed:articleTitle |
Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus.
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pubmed:affiliation |
Futuristic Environmental Simulation Center, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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