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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7362
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pubmed:dateCreated |
2011-9-2
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pubmed:abstractText |
In the central nervous system, ageing results in a precipitous decline in adult neural stem/progenitor cells and neurogenesis, with concomitant impairments in cognitive functions. Interestingly, such impairments can be ameliorated through systemic perturbations such as exercise. Here, using heterochronic parabiosis we show that blood-borne factors present in the systemic milieu can inhibit or promote adult neurogenesis in an age-dependent fashion in mice. Accordingly, exposing a young mouse to an old systemic environment or to plasma from old mice decreased synaptic plasticity, and impaired contextual fear conditioning and spatial learning and memory. We identify chemokines--including CCL11 (also known as eotaxin)--the plasma levels of which correlate with reduced neurogenesis in heterochronic parabionts and aged mice, and the levels of which are increased in the plasma and cerebrospinal fluid of healthy ageing humans. Lastly, increasing peripheral CCL11 chemokine levels in vivo in young mice decreased adult neurogenesis and impaired learning and memory. Together our data indicate that the decline in neurogenesis and cognitive impairments observed during ageing can be in part attributed to changes in blood-borne factors.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/1 F31 AG034045-01,
http://linkedlifedata.com/resource/pubmed/grant/1 F31 NS066676-01A1,
http://linkedlifedata.com/resource/pubmed/grant/DP1 OD000392-01,
http://linkedlifedata.com/resource/pubmed/grant/DP1 OD000392-02,
http://linkedlifedata.com/resource/pubmed/grant/DP1 OD000392-03,
http://linkedlifedata.com/resource/pubmed/grant/DP1 OD000392-04,
http://linkedlifedata.com/resource/pubmed/grant/DP1 OD000392-05,
http://linkedlifedata.com/resource/pubmed/grant/P30AG08017,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG027505-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG027505-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG027505-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG027505-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG027505-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 AR056849-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH078194,
http://linkedlifedata.com/resource/pubmed/grant/R01AG027505
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1476-4687
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pubmed:author |
pubmed-author:AignerLudwigL,
pubmed-author:BieriGregorG,
pubmed-author:BritschgiMarkusM,
pubmed-author:Couillard-DesprésSebastienS,
pubmed-author:CzirrEvaE,
pubmed-author:DingZhaoqingZ,
pubmed-author:EggelAlexanderA,
pubmed-author:FainbergNinaN,
pubmed-author:GalaskoDouglas RDR,
pubmed-author:KayeJeffrey AJA,
pubmed-author:LucinKurt MKM,
pubmed-author:LuoJianJ,
pubmed-author:MosherKira IKI,
pubmed-author:ParkJeong-SooJS,
pubmed-author:PeskindElaine RER,
pubmed-author:QuinnJoseph FJF,
pubmed-author:RandoThomas ATA,
pubmed-author:StanTrisha MTM,
pubmed-author:TYEV MVM,
pubmed-author:VilledaSaul ASA,
pubmed-author:Wyss-CorayTonyT,
pubmed-author:XieXinmin SXS,
pubmed-author:ZouBendeB
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
477
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
90-4
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pubmed:dateRevised |
2011-11-10
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pubmed:meshHeading |
pubmed-meshheading:21886162-Aging,
pubmed-meshheading:21886162-Animals,
pubmed-meshheading:21886162-Chemokine CCL11,
pubmed-meshheading:21886162-Chemokines,
pubmed-meshheading:21886162-Female,
pubmed-meshheading:21886162-Learning,
pubmed-meshheading:21886162-Learning Disorders,
pubmed-meshheading:21886162-Male,
pubmed-meshheading:21886162-Memory Disorders,
pubmed-meshheading:21886162-Mice,
pubmed-meshheading:21886162-Mice, Inbred C57BL,
pubmed-meshheading:21886162-Neurogenesis,
pubmed-meshheading:21886162-Parabiosis,
pubmed-meshheading:21886162-Plasma,
pubmed-meshheading:21886162-Time Factors
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pubmed:year |
2011
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pubmed:articleTitle |
The ageing systemic milieu negatively regulates neurogenesis and cognitive function.
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pubmed:affiliation |
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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