| pubmed-article:2188092 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2188092 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2188092 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:2188092 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2188092 | lifeskim:mentions | umls-concept:C0033713 | lld:lifeskim |
| pubmed-article:2188092 | lifeskim:mentions | umls-concept:C0439677 | lld:lifeskim |
| pubmed-article:2188092 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2188092 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2188092 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2188092 | pubmed:dateCreated | 1990-6-25 | lld:pubmed |
| pubmed-article:2188092 | pubmed:abstractText | The mammalian c-fps/fes proto-oncogene encodes a 92-kilodalton cytoplasmic protein-tyrosine kinase (p92c-fes), which is expressed in immature and differentiated hematopoietic cells of the myeloid lineage. To determine the limits of the c-fps/fes locus and to investigate the cis-acting sequences required to direct appropriate tissue-specific expression, a 13-kilobase-pair fragment of human genomic DNA containing the entire c-fps/fes coding sequence was introduced into the mouse germ line. Transcription of the human c-fps/fes transgene was highest in bone marrow and showed a tissue distribution identical to that of the endogenous mouse gene. Macrophages cultured from transgenic mouse bone marrow contained particularly high levels of human and murine c-fps/fes RNA. Furthermore, expression of human c-fps/fes RNA induced a proportionate increase in the level of the p92c-fes protein-tyrosine kinase in bone marrow, bone marrow-derived macrophages, and spleen. Elevated levels of normal human p92c-fes had no obvious effect on mouse development or hematopoiesis. Remarkably, given the short 5'- and 3'-flanking sequences, expression of the human proto-oncogene in bone marrow was independent of integration site, was proportional to the transgene copy number, and was of comparable efficiency to that of the endogenous mouse c-fps/fes gene. The 13-kilobase-pair fragment therefore defines a genetic locus sufficient for the appropriate tissue-specific expression of the fps/fes protein-tyrosine kinase and includes a dominant cis-acting element that directs integration-independent myeloid expression in transgenic mice. | lld:pubmed |
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| pubmed-article:2188092 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2188092 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2188092 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2188092 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2188092 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:2188092 | pubmed:author | pubmed-author:BernsteinAA | lld:pubmed |
| pubmed-article:2188092 | pubmed:author | pubmed-author:PawsonTT | lld:pubmed |
| pubmed-article:2188092 | pubmed:author | pubmed-author:RossantJJ | lld:pubmed |
| pubmed-article:2188092 | pubmed:author | pubmed-author:GreenTT | lld:pubmed |
| pubmed-article:2188092 | pubmed:author | pubmed-author:MaltbyVV | lld:pubmed |
| pubmed-article:2188092 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2188092 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:2188092 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2188092 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2188092 | pubmed:pagination | 2521-7 | lld:pubmed |
| pubmed-article:2188092 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:2188092 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2188092 | pubmed:articleTitle | Myeloid expression of the human c-fps/fes proto-oncogene in transgenic mice. | lld:pubmed |
| pubmed-article:2188092 | pubmed:affiliation | Division of Molecular and Developmental Biology, Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:2188092 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2188092 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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