Linked Life Data

2188064

Source:http://linkedlifedata.com/resource/pubmed/id/2188064

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-6-28
pubmed:abstractText
To determine the influence of excision repair on the distribution of N-propyl-N'-nitro-N-nitrosoguanidine (PNNG)-induced mutation, we have analysed the DNA sequence changes of mutation induced at the lacI gene of Escherichia coli in a UvrB- strain. The mutagenic specificity was similar to that found in the wild-type strain. Base substitutions predominate; G:C----A:T transitions accounted for almost 75% of the mutational events, while G:C----T:A transversions constituted approximately 20% of the mutations. In both strains the distribution of G:C----A:T transitions was nonrandom, but the site specificity of the G:C----A:T transitions appear dissimilar, with the hot and cold sites occurring at different positions. A single - 1 frameshift was recovered in each strain but deletion events were absent in the excision-repair-deficient strain. The complexity of the sequence-specificity of PNNG might reflect the differential repair of n-propyl and iso-propyl adducts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0267-8357
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-30
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
The influence of excision repair on the distribution of N-propyl-N'-nitro-N-nitrosoguanidine-induced mutation in Escherichia coli.
pubmed:affiliation
Biology Department, York University, Toronto, Ontario, Canada.
pubmed:publicationType
Journal Article, Comparative Study