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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-8-31
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pubmed:abstractText |
Circulating proteins may serve as biomarkers for the early diagnosis and treatment of shock. We have recently demonstrated that treatment with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, significantly improves survival in a rodent model of lipopolysaccharide (LPS)-induced septic shock. Preliminary proteomic data showed that LPS-induced shock altered a number of proteins in circulation, including histone H3 (H3) and citrullinated histone H3 (Cit H3). The present study was designed to confirm these findings and to test whether the pro-survival phenotype could be detected by an early alteration in serum biomarkers.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1532-7361
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pubmed:author |
pubmed-author:AlamHasan BHB,
pubmed-author:ChongWeiW,
pubmed-author:DemoyaMarcM,
pubmed-author:FukudomeEugene YEY,
pubmed-author:JinGuangG,
pubmed-author:KingDavid RDR,
pubmed-author:LiYongqingY,
pubmed-author:LiuBaolingB,
pubmed-author:LiuZhengcaiZ,
pubmed-author:LuJeniferJ,
pubmed-author:VelmahosGeorge CGC
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pubmed:copyrightInfo |
Copyright © 2011 Mosby, Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
442-51
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pubmed:meshHeading |
pubmed-meshheading:21878229-Animals,
pubmed-meshheading:21878229-Biological Markers,
pubmed-meshheading:21878229-Blotting, Western,
pubmed-meshheading:21878229-Citrulline,
pubmed-meshheading:21878229-Disease Models, Animal,
pubmed-meshheading:21878229-Histone Deacetylase Inhibitors,
pubmed-meshheading:21878229-Histones,
pubmed-meshheading:21878229-Hydroxamic Acids,
pubmed-meshheading:21878229-Lipopolysaccharides,
pubmed-meshheading:21878229-Male,
pubmed-meshheading:21878229-Mice,
pubmed-meshheading:21878229-Mice, Inbred C57BL,
pubmed-meshheading:21878229-Random Allocation,
pubmed-meshheading:21878229-Sensitivity and Specificity,
pubmed-meshheading:21878229-Shock, Hemorrhagic,
pubmed-meshheading:21878229-Survival Rate,
pubmed-meshheading:21878229-Tumor Necrosis Factor-alpha
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pubmed:year |
2011
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pubmed:articleTitle |
Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock.
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pubmed:affiliation |
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital/ Harvard Medical School, Boston, MA, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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