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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2011-9-28
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pubmed:abstractText |
Oligophrenin-1 regulates dendritic spine morphology in the brain. Mutations in the oligophrenin-1 gene (OPHN1) cause intellectual disability. We discovered a previously unknown partner of oligophrenin-1, Rev-erb?, a nuclear receptor that represses the transcription of circadian oscillators. We found that oligophrenin-1 interacts with Rev-erb? in the mouse brain, causing it to locate to dendrites, reducing its repressor activity and protecting it from degradation. Our results indicate the presence of a circadian oscillator in the hippocampus, involving the clock gene Bmal1 (also known as Arntl), that is modulated by Rev-erb? and requires oligophrenin-1 for normal oscillation. We also found that synaptic activity induced Rev-erb? localization to dendrites and spines, a process that is mediated by AMPA receptor activation and requires oligophrenin-1. Our data reveal new interactions between synaptic activity and circadian oscillators, and delineate a new means of communication between nucleus and synapse that may provide insight into normal plasticity and the etiology of intellectual disability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,3-dioxo-6-nitro-7-sulfamoylbenzo(f...,
http://linkedlifedata.com/resource/pubmed/chemical/2-amino-5-phosphopentanoic acid,
http://linkedlifedata.com/resource/pubmed/chemical/ARNTL Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Bicuculline,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Proteinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA-A Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Leupeptins,
http://linkedlifedata.com/resource/pubmed/chemical/NR1D1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 1...,
http://linkedlifedata.com/resource/pubmed/chemical/OPHN1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/Valine,
http://linkedlifedata.com/resource/pubmed/chemical/benzyloxycarbonylleucyl-leucyl-leuci...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1546-1726
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pubmed:author |
pubmed-author:BassaniSilviaS,
pubmed-author:BenfanteRobertaR,
pubmed-author:BilluartPierreP,
pubmed-author:ChellyJamelJ,
pubmed-author:DorseuilOlivierO,
pubmed-author:GianfeliceAntonellaA,
pubmed-author:KhelfaouiMalikM,
pubmed-author:LagneauxCelineC,
pubmed-author:PassafaroMariaM,
pubmed-author:SalaCarloC,
pubmed-author:ValnegriPamelaP
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pubmed:copyrightInfo |
© 2011 Nature America, Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1293-301
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pubmed:meshHeading |
pubmed-meshheading:21874017-ARNTL Transcription Factors,
pubmed-meshheading:21874017-Analysis of Variance,
pubmed-meshheading:21874017-Animals,
pubmed-meshheading:21874017-Bicuculline,
pubmed-meshheading:21874017-Cells, Cultured,
pubmed-meshheading:21874017-Cercopithecus aethiops,
pubmed-meshheading:21874017-Cerebral Cortex,
pubmed-meshheading:21874017-Circadian Clocks,
pubmed-meshheading:21874017-Cysteine Proteinase Inhibitors,
pubmed-meshheading:21874017-Cytoskeletal Proteins,
pubmed-meshheading:21874017-Dendrites,
pubmed-meshheading:21874017-Drug Interactions,
pubmed-meshheading:21874017-Embryo, Mammalian,
pubmed-meshheading:21874017-Excitatory Amino Acid Antagonists,
pubmed-meshheading:21874017-GABA-A Receptor Antagonists,
pubmed-meshheading:21874017-GTPase-Activating Proteins,
pubmed-meshheading:21874017-Gene Expression Regulation,
pubmed-meshheading:21874017-Green Fluorescent Proteins,
pubmed-meshheading:21874017-Hippocampus,
pubmed-meshheading:21874017-Humans,
pubmed-meshheading:21874017-Immunoprecipitation,
pubmed-meshheading:21874017-Leupeptins,
pubmed-meshheading:21874017-Mice,
pubmed-meshheading:21874017-Mice, Knockout,
pubmed-meshheading:21874017-Mutation,
pubmed-meshheading:21874017-Neurons,
pubmed-meshheading:21874017-Nuclear Proteins,
pubmed-meshheading:21874017-Nuclear Receptor Subfamily 1, Group D, Member 1,
pubmed-meshheading:21874017-Quinoxalines,
pubmed-meshheading:21874017-RNA, Messenger,
pubmed-meshheading:21874017-RNA, Small Interfering,
pubmed-meshheading:21874017-Rats,
pubmed-meshheading:21874017-Sodium Channel Blockers,
pubmed-meshheading:21874017-Tetrodotoxin,
pubmed-meshheading:21874017-Time Factors,
pubmed-meshheading:21874017-Transfection,
pubmed-meshheading:21874017-Two-Hybrid System Techniques,
pubmed-meshheading:21874017-Valine
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pubmed:year |
2011
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pubmed:articleTitle |
A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erb?.
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pubmed:affiliation |
Consiglio Nazionale delle Ricerche (CNR) Institute of Neuroscience, Department of Pharmacology, University of Milan, Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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