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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0023810,
umls-concept:C0024432,
umls-concept:C0033634,
umls-concept:C0175697,
umls-concept:C0185117,
umls-concept:C0205374,
umls-concept:C0439831,
umls-concept:C0812202,
umls-concept:C1948023,
umls-concept:C2697656,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
1990-6-15
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pubmed:abstractText |
We reported previously that Ets2 is expressed in normal and transformed macrophages. We show here that the expression of both c-ets-2 mRNA proteins is induced rapidly and transiently in chicken nondividing bone marrow-derived macrophages but not in E26-transformed myeloblasts in response to chicken myelomonocytic growth factor (cMGF), an avian hematopoietic growth factor required for survival, proliferation, and colony formation of avian myeloid cells. c-ets-2 expression is also rapidly induced in chicken bone marrow-derived macrophages, human monocytes, and mouse peritoneal macrophages in response to LPS and/or PKC activators. The rapid induction of Ets2 after treatment of chicken bone marrow-derived macrophages by cMGF is blunted after down-regulation or inactivation of PKC, suggesting a role of PKC in the cMGF-induced signal transduction pathway. Because Ets2 is localized in the nucleus of macrophages and binds to DNA in vitro, the kinetics of its expression suggest a role for Ets2 in the transduction within the nucleus of specific signals received at the cell membrane and involved in securing the survival and/or the development of functional competence of these cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Avian Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/MGF protein, chicken,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ets,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
401-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2186967-Animals,
pubmed-meshheading:2186967-Avian Proteins,
pubmed-meshheading:2186967-Cell Line, Transformed,
pubmed-meshheading:2186967-Cells, Cultured,
pubmed-meshheading:2186967-Chickens,
pubmed-meshheading:2186967-DNA-Binding Proteins,
pubmed-meshheading:2186967-Enzyme Activation,
pubmed-meshheading:2186967-Gene Expression,
pubmed-meshheading:2186967-Growth Substances,
pubmed-meshheading:2186967-Humans,
pubmed-meshheading:2186967-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:2186967-Kinetics,
pubmed-meshheading:2186967-Lipopolysaccharides,
pubmed-meshheading:2186967-Macrophages,
pubmed-meshheading:2186967-Mice,
pubmed-meshheading:2186967-Monocytes,
pubmed-meshheading:2186967-Protein Kinase C,
pubmed-meshheading:2186967-Proto-Oncogene Proteins,
pubmed-meshheading:2186967-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:2186967-Proto-Oncogenes,
pubmed-meshheading:2186967-RNA, Messenger,
pubmed-meshheading:2186967-Signal Transduction,
pubmed-meshheading:2186967-Transcription Factors
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pubmed:year |
1990
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pubmed:articleTitle |
Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators.
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pubmed:affiliation |
Institut de la Santé et de la Recherche Médicale U 186/Centre National de la Recherche Scientifique, UA 041160, Institut Pasteur, Lille, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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