|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2011-8-26
|
|
pubmed:abstractText |
The marine natural product (+)-spongistatin 1 is an extremely potent growth inhibitory agent having activity against a wide variety of cancer cell lines, while exhibiting low cytotoxicity against quiescent human fibroblasts. Consistent with a microtubule-targeting mechanism of action, (+)-spongistatin 1 causes mitotic arrest in DU145 human prostate cancer cells. More importantly, (+)-spongistatin 1 exhibits significant in vivo antitumor activity in the LOX-IMVI human melanoma xenograft model. (+)-Spongistatin 1 is, thus, an important class of microtubule targeting anticancer agent that warrants further investigation.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1791-7530
|
|
pubmed:author |
pubmed-author:AtasoyluOnurO,
pubmed-author:HuangKuan-ChunKC,
pubmed-author:LittlefieldBruce ABA,
pubmed-author:LiuJunkeJ,
pubmed-author:MarshJoanneJ,
pubmed-author:NomotoKenichiK,
pubmed-author:QiuDayongD,
pubmed-author:RisattiChristina ACA,
pubmed-author:SmithAmos BAB3rd,
pubmed-author:SperryJeffrey BJB,
pubmed-author:TendykeKarenK,
pubmed-author:XuQunliQ
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
31
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2773-9
|
|
pubmed:meshHeading |
pubmed-meshheading:21868519-Animals,
pubmed-meshheading:21868519-Cell Line, Tumor,
pubmed-meshheading:21868519-Drug Screening Assays, Antitumor,
pubmed-meshheading:21868519-Humans,
pubmed-meshheading:21868519-Macrolides,
pubmed-meshheading:21868519-Mice,
pubmed-meshheading:21868519-Microscopy, Fluorescence,
pubmed-meshheading:21868519-P-Glycoprotein,
pubmed-meshheading:21868519-Stereoisomerism,
pubmed-meshheading:21868519-Tubulin Modulators
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
In vitro and in vivo anticancer activity of (+)-spongistatin 1.
|
|
pubmed:affiliation |
Eisai Inc., 4 Corporate Drive, Andover, MA 01810, USA. qunli_xu@eisai.com
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, N.I.H., Extramural
|
