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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-8-24
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pubmed:abstractText |
Reactive oxygen species (ROS) mediate the effects of anesthetic precondition to protect against ischemia and reperfusion injury, but the mechanisms of ROS generation remain unclear. In this study, the authors investigated if mitochondria-targeted antioxidant (mitotempol) abolishes the cardioprotective effects of anesthetic preconditioning. Further, the authors investigated the mechanism by which isoflurane alters ROS generation in isolated mitochondria and submitochondrial particles.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic N-Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/Electron Transport Complex I,
http://linkedlifedata.com/resource/pubmed/chemical/Electron Transport Complex II,
http://linkedlifedata.com/resource/pubmed/chemical/Electron Transport Complex III,
http://linkedlifedata.com/resource/pubmed/chemical/Electron Transport Complex IV,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflurane,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Rotenone,
http://linkedlifedata.com/resource/pubmed/chemical/Spin Labels,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Uncoupling Agents,
http://linkedlifedata.com/resource/pubmed/chemical/tempol
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1528-1175
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
531-40
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pubmed:meshHeading |
pubmed-meshheading:21862887-Anesthetics, Inhalation,
pubmed-meshheading:21862887-Animals,
pubmed-meshheading:21862887-Cyclic N-Oxides,
pubmed-meshheading:21862887-Electron Transport,
pubmed-meshheading:21862887-Electron Transport Complex I,
pubmed-meshheading:21862887-Electron Transport Complex II,
pubmed-meshheading:21862887-Electron Transport Complex III,
pubmed-meshheading:21862887-Electron Transport Complex IV,
pubmed-meshheading:21862887-Hemodynamics,
pubmed-meshheading:21862887-Ischemic Preconditioning, Myocardial,
pubmed-meshheading:21862887-Isoflurane,
pubmed-meshheading:21862887-Male,
pubmed-meshheading:21862887-Mitochondria, Heart,
pubmed-meshheading:21862887-Myocardial Infarction,
pubmed-meshheading:21862887-Myocardial Reperfusion,
pubmed-meshheading:21862887-Oxygen Consumption,
pubmed-meshheading:21862887-Rats,
pubmed-meshheading:21862887-Rats, Wistar,
pubmed-meshheading:21862887-Reactive Oxygen Species,
pubmed-meshheading:21862887-Rotenone,
pubmed-meshheading:21862887-Spin Labels,
pubmed-meshheading:21862887-Superoxide Dismutase,
pubmed-meshheading:21862887-Uncoupling Agents
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pubmed:year |
2011
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pubmed:articleTitle |
Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: implications for preconditioning.
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pubmed:affiliation |
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. naohirata@mac.com
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, N.I.H., Extramural
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