Linked Life Data

21860597

Source:http://linkedlifedata.com/resource/pubmed/id/21860597

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pubmed-article:21860597pubmed:dateCreated2011-8-23lld:pubmed
pubmed-article:21860597pubmed:abstractTextRegulation of B cell receptor (BCR)-induced Ca(2+) signaling by CD40 co-stimulation was compared in long-term BCR-stimulated immature (WEHI-231) and mature (Bal-17) B cells. In response to long-term pre-stimulation of immature WEHI-231 cells to ?-IgM antibody (0.5~48 hr), the initial transient decrease in BCR-induced [Ca(2+)](i) was followed by spontaneous recovery to control level within 24 hr. The recovery of Ca(2+) signaling in WEHI-231 cells was not due to restoration of internalized receptor but instead to an increase in the levels of PLC?2 and IP(3)R-3. CD40 co-stimulation of WEHI-231 cells prevented BCR-induced cell cycle arrest and apoptosis, and it strongly inhibited the recovery of BCR-induced Ca(2+) signaling. CD40 co-stimulation also enhanced BCR internalization and reduced expression of PLC?2 and IP(3)R-3. Pre-treatment of WEHI-231 cells with the antioxidant N-acetyl-L-cysteine (NAC) strongly inhibited CD40-mediated prevention of the recovery of Ca(2+) signaling. In contrast to immature WEHI-231 cells, identical long-term ?-IgM pre-stimulation of mature Bal-17 cells abolished the increase in BCR-induced [Ca(2+)](i), regardless of CD40 co-stimulation. These results suggest that CD40-mediated signaling prevents antigen-induced cell cycle arrest and apoptosis of immature B cells through inhibition of sustained BCR-induced Ca(2+) signaling.lld:pubmed
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pubmed-article:21860597pubmed:issn1226-4512lld:pubmed
pubmed-article:21860597pubmed:authorpubmed-author:KangTong...lld:pubmed
pubmed-article:21860597pubmed:authorpubmed-author:KimSung...lld:pubmed
pubmed-article:21860597pubmed:authorpubmed-author:KimTae JinTJlld:pubmed
pubmed-article:21860597pubmed:authorpubmed-author:LeeKi-YoungKYlld:pubmed
pubmed-article:21860597pubmed:authorpubmed-author:NguyenYen...lld:pubmed
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pubmed-article:21860597pubmed:volume15lld:pubmed
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pubmed-article:21860597pubmed:pagination179-87lld:pubmed
pubmed-article:21860597pubmed:year2011lld:pubmed
pubmed-article:21860597pubmed:articleTitleCD40 Co-stimulation Inhibits Sustained BCR-induced Ca Signaling in Response to Long-term Antigenic Stimulation of Immature B Cells.lld:pubmed
pubmed-article:21860597pubmed:affiliationDepartment of Physiology, SBRI, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea.lld:pubmed
pubmed-article:21860597pubmed:publicationTypeJournal Articlelld:pubmed