| pubmed-article:21859844 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21859844 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:21859844 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:21859844 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:21859844 | lifeskim:mentions | umls-concept:C0034836 | lld:lifeskim |
| pubmed-article:21859844 | lifeskim:mentions | umls-concept:C0001480 | lld:lifeskim |
| pubmed-article:21859844 | lifeskim:mentions | umls-concept:C1418219 | lld:lifeskim |
| pubmed-article:21859844 | lifeskim:mentions | umls-concept:C1551336 | lld:lifeskim |
| pubmed-article:21859844 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:21859844 | pubmed:dateCreated | 2011-8-30 | lld:pubmed |
| pubmed-article:21859844 | pubmed:abstractText | Extracellular adenosine triphosphate (ATP) can activate purinergic receptors of the plasma membrane and modulate multiple cellular functions. We report that ATP is released from HIV-1 target cells through pannexin-1 channels upon interaction between the HIV-1 envelope protein and specific target cell receptors. Extracellular ATP then acts on purinergic receptors, including P2Y2, to activate proline-rich tyrosine kinase 2 (Pyk2) kinase and transient plasma membrane depolarization, which in turn stimulate fusion between Env-expressing membranes and membranes containing CD4 plus appropriate chemokine co-receptors. Inhibition of any of the constituents of this cascade (pannexin-1, ATP, P2Y2, and Pyk2) impairs the replication of HIV-1 mutant viruses that are resistant to conventional antiretroviral agents. Altogether, our results reveal a novel signaling pathway involved in the early steps of HIV-1 infection that may be targeted with new therapeutic approaches. | lld:pubmed |
| pubmed-article:21859844 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21859844 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21859844 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21859844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21859844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21859844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21859844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21859844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21859844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21859844 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21859844 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:21859844 | pubmed:issn | 1540-9538 | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:MouscadetJean... | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:PerfettiniJea... | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:OjciusDavid... | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:FimiaGian... | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:KroemerGuidoG | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:CasettiRitaR | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:GougeonMarie-... | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:PiacentiniMau... | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:MétivierDidie... | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:FalascaLauraL | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:LamazeChristo... | lld:pubmed |
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| pubmed-article:21859844 | pubmed:author | pubmed-author:Kanellopoulos... | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:ThierrySylvai... | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:VoisinLaurent... | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:BrasMarlèneM | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:SaïdiHélaH | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:MartinsIsabel... | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:SérorClaireC | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:MelkiMarie-Th... | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:RazaSyed... | lld:pubmed |
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| pubmed-article:21859844 | pubmed:author | pubmed-author:PaolettiAudre... | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:LawFrédéricF | lld:pubmed |
| pubmed-article:21859844 | pubmed:author | pubmed-author:Said-SadierNa... | lld:pubmed |
| pubmed-article:21859844 | pubmed:copyrightInfo | © 2011 Séror et al. | lld:pubmed |
| pubmed-article:21859844 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21859844 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:21859844 | pubmed:volume | 208 | lld:pubmed |
| pubmed-article:21859844 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21859844 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21859844 | pubmed:pagination | 1823-34 | lld:pubmed |
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| pubmed-article:21859844 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21859844 | pubmed:articleTitle | Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection. | lld:pubmed |
| pubmed-article:21859844 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale (INSERM) U848, F-94805 Villejuif, France. | lld:pubmed |
| pubmed-article:21859844 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21859844 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21859844 | lld:entrezgene |
