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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2011-8-30
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pubmed:abstractText |
Extracellular adenosine triphosphate (ATP) can activate purinergic receptors of the plasma membrane and modulate multiple cellular functions. We report that ATP is released from HIV-1 target cells through pannexin-1 channels upon interaction between the HIV-1 envelope protein and specific target cell receptors. Extracellular ATP then acts on purinergic receptors, including P2Y2, to activate proline-rich tyrosine kinase 2 (Pyk2) kinase and transient plasma membrane depolarization, which in turn stimulate fusion between Env-expressing membranes and membranes containing CD4 plus appropriate chemokine co-receptors. Inhibition of any of the constituents of this cascade (pannexin-1, ATP, P2Y2, and Pyk2) impairs the replication of HIV-1 mutant viruses that are resistant to conventional antiretroviral agents. Altogether, our results reveal a novel signaling pathway involved in the early steps of HIV-1 infection that may be targeted with new therapeutic approaches.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1540-9538
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pubmed:author |
pubmed-author:Abdul-SaterAli AAA,
pubmed-author:AmendolaAlessandraA,
pubmed-author:BrasMarlèneM,
pubmed-author:CasettiRitaR,
pubmed-author:CiccosantiFabiolaF,
pubmed-author:DelelisOlivierO,
pubmed-author:EstaquierJéromeJ,
pubmed-author:FalascaLauraL,
pubmed-author:FimiaGian MariaGM,
pubmed-author:GougeonMarie-LiseML,
pubmed-author:KanellopoulosJeanJ,
pubmed-author:KroemerGuidoG,
pubmed-author:LamazeChristopheC,
pubmed-author:LawFrédéricF,
pubmed-author:MétivierDidierD,
pubmed-author:MartinsIsabelleI,
pubmed-author:MelkiMarie-ThérèseMT,
pubmed-author:ModjtahediNazanineN,
pubmed-author:MouscadetJean-FrançoisJF,
pubmed-author:NardacciRobertaR,
pubmed-author:NiedergangFlorenceF,
pubmed-author:OjciusDavid MDM,
pubmed-author:PaolettiAudreyA,
pubmed-author:PerfettiniJean-LucJL,
pubmed-author:PiacentiniMauroM,
pubmed-author:RazaSyed QasimSQ,
pubmed-author:SérorClaireC,
pubmed-author:SaïdiHélaH,
pubmed-author:Said-SadierNajwaneN,
pubmed-author:SubraFrédéricF,
pubmed-author:ThierrySylvainS,
pubmed-author:VoisinLaurentL
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pubmed:copyrightInfo |
© 2011 Séror et al.
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pubmed:issnType |
Electronic
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pubmed:day |
29
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pubmed:volume |
208
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1823-34
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pubmed:meshHeading |
pubmed-meshheading:21859844-Adenosine Triphosphate,
pubmed-meshheading:21859844-Adult,
pubmed-meshheading:21859844-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:21859844-Cell Membrane,
pubmed-meshheading:21859844-Connexins,
pubmed-meshheading:21859844-Drug Resistance, Viral,
pubmed-meshheading:21859844-Enzyme Activation,
pubmed-meshheading:21859844-Focal Adhesion Kinase 2,
pubmed-meshheading:21859844-HIV Infections,
pubmed-meshheading:21859844-HIV-1,
pubmed-meshheading:21859844-Humans,
pubmed-meshheading:21859844-Male,
pubmed-meshheading:21859844-Mutation,
pubmed-meshheading:21859844-Nerve Tissue Proteins,
pubmed-meshheading:21859844-Receptors, Purinergic P2Y2,
pubmed-meshheading:21859844-Signal Transduction,
pubmed-meshheading:21859844-Virus Replication
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pubmed:year |
2011
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pubmed:articleTitle |
Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection.
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pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale (INSERM) U848, F-94805 Villejuif, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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