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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
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|
pubmed:dateCreated |
1990-6-12
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|
pubmed:abstractText |
Insulin-dependent diabetes mellitus results from the autoimmune destruction of the insulin-producing beta cells of the pancreatic islets. The target antigen(s) involved in this immunopathological process has not been identified. Our strategy was to determine whether expression of a novel surface antigen by murine pancreatic beta cells would result in insulin-dependent diabetes mellitus. We have generated lines of transgenic mice (RIP-HA) that express the hemagglutinin of the A/Japan/305/57 strain of influenza virus on their insulin-producing beta cells. Hyperglycemia developed in mice derived from all three founders at a frequency varying from 13% to 27%, and was associated with lymphocytic infiltration of the islets and a humoral response against beta cell antigens, including hemagglutinin. These results suggest that the RIP-HA mice should provide a useful system in which to study the cellular interactions involved in the induction of self-tolerance and autoimmunity.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
May
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pubmed:issn |
0092-8674
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
4
|
|
pubmed:volume |
61
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
383-96
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pubmed:dateRevised |
2005-11-22
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pubmed:meshHeading |
pubmed-meshheading:2185889-Animals,
pubmed-meshheading:2185889-Autoantibodies,
pubmed-meshheading:2185889-Autoimmune Diseases,
pubmed-meshheading:2185889-Blood Glucose,
pubmed-meshheading:2185889-Diabetes Mellitus, Experimental,
pubmed-meshheading:2185889-Female,
pubmed-meshheading:2185889-Fluorescent Antibody Technique,
pubmed-meshheading:2185889-Gene Expression,
pubmed-meshheading:2185889-Hemagglutinin Glycoproteins, Influenza Virus,
pubmed-meshheading:2185889-Hemagglutinins, Viral,
pubmed-meshheading:2185889-Influenza A virus,
pubmed-meshheading:2185889-Islets of Langerhans,
pubmed-meshheading:2185889-Male,
pubmed-meshheading:2185889-Mice,
pubmed-meshheading:2185889-Mice, Transgenic,
pubmed-meshheading:2185889-Pedigree,
pubmed-meshheading:2185889-Viral Envelope Proteins
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|
pubmed:year |
1990
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|
pubmed:articleTitle |
The expression of influenza virus hemagglutinin in the pancreatic beta cells of transgenic mice results in autoimmune diabetes.
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|
pubmed:affiliation |
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas.
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pubmed:publicationType |
Journal Article
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