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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2011-8-31
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pubmed:abstractText |
MicroRNA-124a (miR-124a) is the most abundant microRNA expressed in the vertebrate CNS. Despite past investigations into the role of miR-124a, inconsistent results have left the in vivo function of miR-124a unclear. We examined the in vivo function of miR-124a by targeted disruption of Rncr3 (retinal non-coding RNA 3), the dominant source of miR-124a. Rncr3(-/-) mice exhibited abnormalities in the CNS, including small brain size, axonal mis-sprouting of dentate gyrus granule cells and retinal cone cell death. We found that Lhx2 is an in vivo target mRNA of miR-124a. We also observed that LHX2 downregulation by miR-124a is required for the prevention of apoptosis in the developing retina and proper axonal development of hippocampal neurons. These results suggest that miR-124a is essential for the maturation and survival of dentate gyrus neurons and retinal cones, as it represses Lhx2 translation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/LIM-Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lhx2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/MicroRNAs,
http://linkedlifedata.com/resource/pubmed/chemical/Mirn124 microRNA, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Untranslated,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/prospero-related homeobox 1 protein
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1546-1726
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pubmed:author |
pubmed-author:ChérasseYoanY,
pubmed-author:FurukawaTakahisaT,
pubmed-author:IrieShoichiS,
pubmed-author:KoikeChiekoC,
pubmed-author:KondoMineoM,
pubmed-author:KoyasuToshiyukiT,
pubmed-author:MatsuiRyosukeR,
pubmed-author:MuramatsuRiekoR,
pubmed-author:MuranishiYukiY,
pubmed-author:OnishiAkishiA,
pubmed-author:SanukiRikakoR,
pubmed-author:UneoShinjiS,
pubmed-author:UradeYoshihiroY,
pubmed-author:WatanabeDaiD,
pubmed-author:WatanabeSatoshiS,
pubmed-author:YamashitaToshihideT
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1125-34
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21857657-Analysis of Variance,
pubmed-meshheading:21857657-Animals,
pubmed-meshheading:21857657-Animals, Newborn,
pubmed-meshheading:21857657-Axons,
pubmed-meshheading:21857657-Brain,
pubmed-meshheading:21857657-Cell Differentiation,
pubmed-meshheading:21857657-Cell Survival,
pubmed-meshheading:21857657-Electroporation,
pubmed-meshheading:21857657-Electroretinography,
pubmed-meshheading:21857657-Embryo, Mammalian,
pubmed-meshheading:21857657-Evoked Potentials, Visual,
pubmed-meshheading:21857657-Gene Expression Regulation, Developmental,
pubmed-meshheading:21857657-Hippocampus,
pubmed-meshheading:21857657-Homeodomain Proteins,
pubmed-meshheading:21857657-In Situ Nick-End Labeling,
pubmed-meshheading:21857657-LIM-Homeodomain Proteins,
pubmed-meshheading:21857657-Mice,
pubmed-meshheading:21857657-Mice, Transgenic,
pubmed-meshheading:21857657-MicroRNAs,
pubmed-meshheading:21857657-Neurons,
pubmed-meshheading:21857657-RNA, Small Interfering,
pubmed-meshheading:21857657-RNA, Untranslated,
pubmed-meshheading:21857657-Retina,
pubmed-meshheading:21857657-Retinal Cone Photoreceptor Cells,
pubmed-meshheading:21857657-Tissue Culture Techniques,
pubmed-meshheading:21857657-Transcription Factors,
pubmed-meshheading:21857657-Tumor Suppressor Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression.
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pubmed:affiliation |
Department of Developmental Biology, Osaka Bioscience Institute, Suita, Osaka, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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