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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2011-8-19
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pubmed:abstractText |
In plants and animals, the NLR family of receptors perceives non-self and modified-self molecules inside host cells and mediates innate immune responses to microbial pathogens. Despite their similar biological functions and protein architecture, animal NLRs are normally activated by conserved microbe- or damage-associated molecular patterns, whereas plant NLRs typically detect strain-specific pathogen effectors. Plant NLRs recognize either the effector structure or effector-mediated modifications of host proteins. The latter indirect mechanism for the perception of non-self, as well as the within-species diversification of plant NLRs, maximize the capacity to recognize non-self through the use of a finite number of innate immunoreceptors. We discuss recent insights into NLR activation, signal initiation through the homotypic association of N-terminal domains and subcellular receptor dynamics in plants and compare those with NLR functions in animals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1529-2916
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
817-26
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pubmed:meshHeading |
pubmed-meshheading:21852785-Animals,
pubmed-meshheading:21852785-Bacteria,
pubmed-meshheading:21852785-Biological Evolution,
pubmed-meshheading:21852785-Cell Death,
pubmed-meshheading:21852785-Cytokines,
pubmed-meshheading:21852785-Fungi,
pubmed-meshheading:21852785-Gene Expression Regulation, Plant,
pubmed-meshheading:21852785-Genetic Heterogeneity,
pubmed-meshheading:21852785-Host-Parasite Interactions,
pubmed-meshheading:21852785-Immunity, Innate,
pubmed-meshheading:21852785-Mice,
pubmed-meshheading:21852785-Plant Growth Regulators,
pubmed-meshheading:21852785-Plant Immunity,
pubmed-meshheading:21852785-Plant Proteins,
pubmed-meshheading:21852785-Plants,
pubmed-meshheading:21852785-Protein Multimerization,
pubmed-meshheading:21852785-Receptors, G-Protein-Coupled,
pubmed-meshheading:21852785-Receptors, Pattern Recognition,
pubmed-meshheading:21852785-Signal Transduction
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pubmed:year |
2011
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pubmed:articleTitle |
NLR functions in plant and animal immune systems: so far and yet so close.
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pubmed:affiliation |
Max-Planck Institute for Plant Breeding Research, Department of Plant-Microbe Interactions, Köln, Germany.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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