|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2011-8-30
|
|
pubmed:abstractText |
Carbon monoxide (CO) is a gaseous second messenger produced when heme oxygenase enzymes catabolize heme. We have demonstrated that CO can be therapeutic in ischemia-reperfusion brain injury; however, it is unclear whether CO can also offer protection in permanent ischemic stroke or what mechanism(s) underlies the effect. Heme oxygenase-1 neuroprotection was shown to be regulated by Nrf2; therefore, we investigated whether CO might partially exert neuroprotection by modulating the Nrf2 pathway.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Monoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase-1,
http://linkedlifedata.com/resource/pubmed/chemical/Keap1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/NF-E2-Related Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nfe2l2 protein, mouse
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1524-4628
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
42
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2605-10
|
|
pubmed:meshHeading |
pubmed-meshheading:21852618-Active Transport, Cell Nucleus,
pubmed-meshheading:21852618-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:21852618-Animals,
pubmed-meshheading:21852618-Antimetabolites,
pubmed-meshheading:21852618-Brain Ischemia,
pubmed-meshheading:21852618-Carbon Monoxide,
pubmed-meshheading:21852618-Cell Nucleus,
pubmed-meshheading:21852618-Cytoskeletal Proteins,
pubmed-meshheading:21852618-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:21852618-Heme Oxygenase-1,
pubmed-meshheading:21852618-Male,
pubmed-meshheading:21852618-Mice,
pubmed-meshheading:21852618-Mice, Knockout,
pubmed-meshheading:21852618-NF-E2-Related Factor 2,
pubmed-meshheading:21852618-Neuroprotective Agents,
pubmed-meshheading:21852618-Response Elements,
pubmed-meshheading:21852618-Stroke,
pubmed-meshheading:21852618-Time Factors
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia.
|
|
pubmed:affiliation |
Center for Translational Research in Neurodegenerative Disease, University of Florida, 1275 Center Dr, Biomed Sci J493, PO 100159, Gainesville, FL 32610, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
