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pubmed:abstractText |
The relationship of intracellular Na+ K+ Li+ to their extracellular concentrations had been studied on 22 cases bipolar affective disorders who had been on prophylactic lithium. 6 of these cases were nonresponders who were admitted repeatedly despite a therapeutic serum lithium values of 0.8-1.1 m moi/L. Parameters measured were Plasma lithium (Lp), Erythrocyte Lithium (Le), Plasma potassium (Kp), Erythrocyte potassium, Ke) Plasma sodium (Nae). Eli had been calculated by using Nerst's equation. Significant correlations have been obtained for dosage and Lp, Lp and Le, and Lp and Le/Lp. There were no significant difference between the responders and non-responders as regards to values of Le, Lp, Nap, Nae, Kp and Ke.
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