Source:http://linkedlifedata.com/resource/pubmed/id/21844391
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2011-9-8
|
| pubmed:abstractText |
Contrasting results have emerged from studies performed using IL-12p35(-/-) mice. Animals lacking the IL-12p35 subunit can either be protected from or develop exacerbated autoimmune diseases, intracellular infections, and delayed-type hypersensitivity responses. In this study, we report that mice lacking the IL-12p35 subunit develop a significantly milder Ag-induced arthritis compared with wild-type (WT) mice. Lack of severe inflammation is accompanied by an increase in the mRNA levels of the Ebi-3 and p28 subunits and increased secretion of IL-27 and IL-10. This anti-inflammatory environment contributed to increased differentiation of regulatory T and B cells with intact suppressive function. Furthermore, IL-12p35(-/-) mice display reduced numbers of Th17 cells compared with WT arthritic mice. Neutralization of IL-27, but not the systemic administration of IL-12, restored inflammation and Th17 to levels seen in WT mice. The restoration of disease phenotype after anti-IL-27 administration indicates that the IL-12p35 subunit acts as negative regulator of the developing IL-27 response in this model of arthritis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1550-6606
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
187
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3402-12
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| pubmed:meshHeading |
pubmed-meshheading:21844391-Animals,
pubmed-meshheading:21844391-Arthritis, Experimental,
pubmed-meshheading:21844391-Autoimmunity,
pubmed-meshheading:21844391-B-Lymphocytes,
pubmed-meshheading:21844391-Cell Differentiation,
pubmed-meshheading:21844391-Cell Separation,
pubmed-meshheading:21844391-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21844391-Female,
pubmed-meshheading:21844391-Flow Cytometry,
pubmed-meshheading:21844391-Interleukin-12 Subunit p35,
pubmed-meshheading:21844391-Interleukins,
pubmed-meshheading:21844391-Lymphocyte Activation,
pubmed-meshheading:21844391-Mice,
pubmed-meshheading:21844391-Mice, Inbred C57BL,
pubmed-meshheading:21844391-Mice, Knockout,
pubmed-meshheading:21844391-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21844391-T-Lymphocytes, Regulatory
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
IL-12p35 subunit contributes to autoimmunity by limiting IL-27-driven regulatory responses.
|
| pubmed:affiliation |
Centre for Rheumatology Research, University College London, London WC1E 6JF, United Kingdom.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|