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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-8-16
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pubmed:abstractText |
Iron overload can adversely influence the course of infection by increasing microbial replication and suppressing antimicrobial immune effector pathways. Recently, we have shown that the calcium channel blocker nifedipine can mobilize tissue iron in mouse models of iron overload. We therefore investigated whether nifedipine treatment affects the course of infection with intracellular bacteria via modulation of iron homeostasis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1537-6613
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
204
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
685-94
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pubmed:dateRevised |
2011-10-31
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pubmed:meshHeading |
pubmed-meshheading:21844295-Animals,
pubmed-meshheading:21844295-Bacterial Load,
pubmed-meshheading:21844295-Calcium Channel Blockers,
pubmed-meshheading:21844295-Cation Transport Proteins,
pubmed-meshheading:21844295-Cell Line,
pubmed-meshheading:21844295-Chlamydophila Infections,
pubmed-meshheading:21844295-Chlamydophila pneumoniae,
pubmed-meshheading:21844295-Cytokines,
pubmed-meshheading:21844295-Ferritins,
pubmed-meshheading:21844295-Iron,
pubmed-meshheading:21844295-Liver,
pubmed-meshheading:21844295-Macrophages,
pubmed-meshheading:21844295-Male,
pubmed-meshheading:21844295-Mice,
pubmed-meshheading:21844295-Mice, Inbred C57BL,
pubmed-meshheading:21844295-Nifedipine,
pubmed-meshheading:21844295-RNA, Messenger,
pubmed-meshheading:21844295-Salmonella Infections, Animal,
pubmed-meshheading:21844295-Salmonella typhimurium,
pubmed-meshheading:21844295-Spleen
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pubmed:year |
2011
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pubmed:articleTitle |
Nifedipine affects the course of Salmonella enterica serovar Typhimurium infection by modulating macrophage iron homeostasis.
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pubmed:affiliation |
Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Austria. guenter.weiss@i-med.ac.at
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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