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rdf:type |
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lifeskim:mentions |
umls-concept:C0017278,
umls-concept:C0019704,
umls-concept:C0020971,
umls-concept:C0039195,
umls-concept:C0085358,
umls-concept:C0085408,
umls-concept:C0205263,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1422036,
umls-concept:C1706438,
umls-concept:C1998793,
umls-concept:C2698600
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pubmed:issue |
6269
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pubmed:dateCreated |
1990-5-30
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pubmed:abstractText |
To reduce the risks of immunization with killed or live attenuated virus vaccines, it may be advantageous to use a pure, defined antigen that contains determinants for both humoral and cellular immunity. However, although most non-living intact protein preparations induce antibodies and CD4+ major histocompatibility complex (MHC) class II-restricted helper and/or cytotoxic T lymphocytes (CTL), they do not elicit CD8+ MHC class I restricted CTL. Indeed, with a few exceptions, it has not so far been possible to induce CD8+ CTL by immunizing with intact soluble proteins. We show here that a single subcutaneous immunization in mice with immunostimulating complexes containing either purified intact gp160 envelope glycoprotein of the human immunodeficiency virus (HIV)-1 or influenza haemagglutinin results in reproducible and long-lasting priming of HIV specific or influenza-specific CD8+, MHC class I restricted CTL.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, env,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp160,
http://linkedlifedata.com/resource/pubmed/chemical/Hemagglutinin Glycoproteins...,
http://linkedlifedata.com/resource/pubmed/chemical/Hemagglutinins, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Quil A,
http://linkedlifedata.com/resource/pubmed/chemical/Saponins,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Synthetic
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
344
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
873-5
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2184369-Adjuvants, Immunologic,
pubmed-meshheading:2184369-Amino Acid Sequence,
pubmed-meshheading:2184369-Animals,
pubmed-meshheading:2184369-Gene Products, env,
pubmed-meshheading:2184369-HIV Antigens,
pubmed-meshheading:2184369-HIV Envelope Protein gp160,
pubmed-meshheading:2184369-HIV-1,
pubmed-meshheading:2184369-Hemagglutinin Glycoproteins, Influenza Virus,
pubmed-meshheading:2184369-Hemagglutinins, Viral,
pubmed-meshheading:2184369-Histocompatibility Antigens Class I,
pubmed-meshheading:2184369-Immunization,
pubmed-meshheading:2184369-Mice,
pubmed-meshheading:2184369-Mice, Inbred BALB C,
pubmed-meshheading:2184369-Molecular Sequence Data,
pubmed-meshheading:2184369-Protein Precursors,
pubmed-meshheading:2184369-Saponins,
pubmed-meshheading:2184369-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:2184369-Vaccines, Synthetic
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pubmed:year |
1990
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pubmed:articleTitle |
Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs.
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pubmed:affiliation |
Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article
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