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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2011-9-8
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pubmed:abstractText |
Ig? serine 191 and 197 and threonine 203, which are located in proximity of the Ig? ITAM, dampen Ig? ITAM tyrosine phosphorylation. In this study, we show that mice with targeted mutations of Ig? S191, 197, and T203 displayed elevated serum IgG2c and IgG2b concentrations and had elevated numbers of IgG2c- and IgG2b-secreting cells in the bone marrow. BCR-induced Ig? tyrosine phosphorylation was slightly increased in splenic B cells. Our results suggest that Ig? serine/threonines limit formation of IgG2c- and IgG2b-secreting bone marrow plasma cells, possibly by fine-tuning Ig? tyrosine-mediated BCR signaling.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1550-6606
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
187
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2853-8
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pubmed:meshHeading |
pubmed-meshheading:21841126-Amino Acid Sequence,
pubmed-meshheading:21841126-Animals,
pubmed-meshheading:21841126-Bone Marrow Cells,
pubmed-meshheading:21841126-Cell Differentiation,
pubmed-meshheading:21841126-Cell Separation,
pubmed-meshheading:21841126-Cytoplasm,
pubmed-meshheading:21841126-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21841126-Flow Cytometry,
pubmed-meshheading:21841126-Immunoblotting,
pubmed-meshheading:21841126-Mice,
pubmed-meshheading:21841126-Mice, Inbred C57BL,
pubmed-meshheading:21841126-Molecular Sequence Data,
pubmed-meshheading:21841126-Mutation,
pubmed-meshheading:21841126-Phosphorylation,
pubmed-meshheading:21841126-Plasma Cells,
pubmed-meshheading:21841126-Receptors, Antigen, B-Cell,
pubmed-meshheading:21841126-Serine,
pubmed-meshheading:21841126-Signal Transduction,
pubmed-meshheading:21841126-Threonine,
pubmed-meshheading:21841126-Tyrosine
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pubmed:year |
2011
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pubmed:articleTitle |
Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation.
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pubmed:affiliation |
Program in Cellular and Molecular Medicine at Children's Hospital Boston and Immune Disease Institute, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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