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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1990-5-25
|
| pubmed:abstractText |
In the present paper we have investigated the effects of aromatic tetra-amidines on attachment, oriented migration and in vitro invasiveness of the Chinese Hamster FH06T1-1 fibroblast lung cell line, transformed with the activated human T24-Ha-ras-1 oncogene. The FH06T1-1 cell line is tumorigenic in nude mice and displays growth properties and biological features clearly distinct from those of the FH06N1-1 cell line, obtained after transfection of the same fibroblast cells with the normal Ha-ras-1 proto-oncogene. Attachment, oriented migration and invasiveness were analysed by culturing the cells on a reconstituted extracellular matrix, composed of collagen IV, laminin, entactin and heparan sulphate proteoglycans. The results obtained demonstrate that oriented migration is performed only by FH06T1-1 cells and that tetra-benzamidines are effective inhibitors of oriented migration and "in vitro" invasiveness of these tumorigenic cells. These findings should encourage further studies on the possible antimetastatic effects of these antiproteinase tetra-benzamidines on experimental animals.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4,4'-(2,2-bis((4-(aminoiminomethyl)-...,
http://linkedlifedata.com/resource/pubmed/chemical/Amidines,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzamidines,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Protein p21(ras),
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0304-3835
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
50
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
93-102
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2183928-Amidines,
pubmed-meshheading:2183928-Animals,
pubmed-meshheading:2183928-Antineoplastic Agents,
pubmed-meshheading:2183928-Benzamidines,
pubmed-meshheading:2183928-Cell Division,
pubmed-meshheading:2183928-Cell Movement,
pubmed-meshheading:2183928-Chemical Phenomena,
pubmed-meshheading:2183928-Chemistry,
pubmed-meshheading:2183928-Cricetinae,
pubmed-meshheading:2183928-Cricetulus,
pubmed-meshheading:2183928-Depression, Chemical,
pubmed-meshheading:2183928-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:2183928-Genes, ras,
pubmed-meshheading:2183928-Humans,
pubmed-meshheading:2183928-Neoplasm Invasiveness,
pubmed-meshheading:2183928-Oncogene Protein p21(ras),
pubmed-meshheading:2183928-Protease Inhibitors,
pubmed-meshheading:2183928-Transfection,
pubmed-meshheading:2183928-Tumor Cells, Cultured
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Tetra-amidines exhibiting anti-proteinase activity: effects on oriented migration and in vitro invasiveness of a Chinese hamster cell line transfected with the activated human T24-Ha-ras-1 oncogene.
|
| pubmed:affiliation |
Dip. di Scienze Farmaceutiche, Universita di Ferrara, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|