Source:http://linkedlifedata.com/resource/pubmed/id/21826156
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2011-8-9
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pubmed:abstractText |
Renal toxicity by melamine in combination with cyanuric acid (1:1) was investigated. Male rats were orally administered melamine plus cyanuric acid (5, 50 or 400 mg/kg each) for 3 days. In contrast to a negligible effect by melamine alone (50 mg/kg, a no-observed-adverse-effect-level: NOAEL), co-administration with cyanuric acid markedly increased the concentrations of blood urea nitrogen and creatinine, as well as kidney weight. A high dose (400 mg/kg) of melamine plus cyanuric acid induced more severe kidney toxicity. The increased blood parameters for kidney toxicity and organ weight lasted longer than 4 days. Combined treatment with melamine and cyanuric acid (50-400 mg/kg each) resulted in many gold-brown crystals and toxic lesions in renal tubules, which were not observed in animals treated with melamine alone (50 mg/kg). These results indicate that only a 3-day exposure to melamine in combination with cyanuric acid causes severe renal damage, even at a NOAEL for melamine found in a 13-week toxicity study. Therefore, it is suggested that the tolerable daily intake or regulatory/management levels of melamine need to be re-considered for cases of co-exposure with cyanuric acid.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21826156-115586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21826156-17823396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21826156-17998549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21826156-18689873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21826156-19109571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21826156-1962191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21826156-3545805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21826156-3904735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21826156-8470356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21826156-883089
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pubmed:language |
eng
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pubmed:journal | |
pubmed:status |
PubMed-not-MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
2233-7660
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pubmed:author |
pubmed-author:AhnByeongwooB,
pubmed-author:BaeDae-KwonDK,
pubmed-author:ChoiEhn-KyoungEK,
pubmed-author:ChoiYoung JinYJ,
pubmed-author:JooSeong SooSS,
pubmed-author:KimJong-ChoonJC,
pubmed-author:KimKil-SooKS,
pubmed-author:KimTae KyunTK,
pubmed-author:KimYun-BaeYB,
pubmed-author:LeeSun HeeSH,
pubmed-author:ParkDongsunD,
pubmed-author:YangGoeunG,
pubmed-author:YangYun-HuiYH
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-8
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pubmed:year |
2011
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pubmed:articleTitle |
Increased nephrotoxicity after combined administration of melamine and cyanuric Acid in rats.
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pubmed:affiliation |
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
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pubmed:publicationType |
Journal Article
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