rdf:type |
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0013081,
umls-concept:C0017262,
umls-concept:C0027215,
umls-concept:C0042172,
umls-concept:C0185117,
umls-concept:C0533325,
umls-concept:C0547047,
umls-concept:C0595989,
umls-concept:C0600210,
umls-concept:C1269955,
umls-concept:C1421244,
umls-concept:C1704897,
umls-concept:C1998811,
umls-concept:C2699153,
umls-concept:C2911684
|
pubmed:issue |
10
|
pubmed:dateCreated |
2011-9-14
|
pubmed:abstractText |
The transcription factor TWIST is an important factor in regulation of the epithelial-mesenchymal transition (EMT), which represents the primary stages during the metastasis of tumors. To identify the role of TWIST in the regulation of metastasis in laryngeal carcinoma Hep-2 cells, we investigated whether the alteration of TWIST has an effect on the Hep-2 cells morphology and whether the alteration of TWIST has an effect on the expression of E-cadherin, N-cadherin as well as the ability of cell motion, migration, and invasion.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
1432-1335
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
137
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1487-93
|
pubmed:meshHeading |
pubmed-meshheading:21822911-Antigens, CD,
pubmed-meshheading:21822911-Base Sequence,
pubmed-meshheading:21822911-Cadherins,
pubmed-meshheading:21822911-Cell Adhesion,
pubmed-meshheading:21822911-Cell Line, Tumor,
pubmed-meshheading:21822911-Cell Movement,
pubmed-meshheading:21822911-Down-Regulation,
pubmed-meshheading:21822911-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21822911-Humans,
pubmed-meshheading:21822911-Laryngeal Neoplasms,
pubmed-meshheading:21822911-Molecular Sequence Data,
pubmed-meshheading:21822911-Neoplasm Invasiveness,
pubmed-meshheading:21822911-Twist Transcription Factor
|
pubmed:year |
2011
|
pubmed:articleTitle |
Down-regulation of TWIST decreases migration and invasion of laryngeal carcinoma Hep-2 cells by regulating the E-cadherin, N-cadherin expression.
|
pubmed:affiliation |
Department of Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Peoples' Republic of China.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|