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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0024432,
umls-concept:C0033414,
umls-concept:C0185117,
umls-concept:C1148932,
umls-concept:C1412058,
umls-concept:C1412096,
umls-concept:C1515655,
umls-concept:C1533691,
umls-concept:C2246761,
umls-concept:C2911684
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pubmed:issue |
9
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pubmed:dateCreated |
2011-8-18
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pubmed:abstractText |
ATP-binding cassette transporter A1 (ABCA1) and ABCG1 are key molecules in an initial step of reverse cholesterol transport (RCT), a major antiatherogenic property of high-density lipoprotein (HDL). The ubiquitin-proteasome system (UPS) mediates nonlysosomal pathways for protein degradation and is known to be involved in atherosclerosis. However, little is known about the effects of the UPS on these molecules and overall RCT. We therefore investigated whether UPS inhibition affects ABCA1/G1 expression in macrophages and RCT in vitro and in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ABCG1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ABCG1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/ATP binding cassette transporter 1,
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Boronic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/bortezomib
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4636
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pubmed:author |
pubmed-author:AyaoriMakotoM,
pubmed-author:HisadaTetsuyaT,
pubmed-author:IizukaMakiM,
pubmed-author:IkewakiKatsunoriK,
pubmed-author:KomatsuTomohiroT,
pubmed-author:NakayaKazuhiroK,
pubmed-author:OguraMasatsuneM,
pubmed-author:OhsuzuFumitakaF,
pubmed-author:OzasaHidekiH,
pubmed-author:SasakiMakotoM,
pubmed-author:TakiguchiShunichiS,
pubmed-author:TeraoYoshioY,
pubmed-author:Uto-KondoHarumiH,
pubmed-author:YakushijiEmiE
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1980-7
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pubmed:meshHeading |
pubmed-meshheading:21817095-ATP-Binding Cassette Transporters,
pubmed-meshheading:21817095-Animals,
pubmed-meshheading:21817095-Apolipoprotein A-I,
pubmed-meshheading:21817095-Boronic Acids,
pubmed-meshheading:21817095-Cells, Cultured,
pubmed-meshheading:21817095-Cholesterol,
pubmed-meshheading:21817095-Hep G2 Cells,
pubmed-meshheading:21817095-Humans,
pubmed-meshheading:21817095-Lipoproteins,
pubmed-meshheading:21817095-Lipoproteins, HDL,
pubmed-meshheading:21817095-Macrophages,
pubmed-meshheading:21817095-Mice,
pubmed-meshheading:21817095-Phosphorylation,
pubmed-meshheading:21817095-Proteasome Endopeptidase Complex,
pubmed-meshheading:21817095-Pyrazines,
pubmed-meshheading:21817095-Ubiquitin-Protein Ligases,
pubmed-meshheading:21817095-Ubiquitination
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pubmed:year |
2011
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pubmed:articleTitle |
Proteasomal inhibition promotes ATP-binding cassette transporter A1 (ABCA1) and ABCG1 expression and cholesterol efflux from macrophages in vitro and in vivo.
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pubmed:affiliation |
Division of Anti-aging, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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