Linked Life Data

21810622

Source:http://linkedlifedata.com/resource/pubmed/id/21810622

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2011-9-15
pubmed:abstractText
The role played by genetic components in the etiology of the Class III phenotype, a class of dental malocclusion, is not yet understood. Regions that may be related to the development of Class III malocclusion have been suggested previously. The aim of this study was to search for genetic linkage with 6 microsatellite markers (D1S234, D4S3038, D6S1689, D7S503, D10S1483, and D19S566), near previously proposed candidate regions for Class III. We performed a two-point parametric linkage analysis for 42 affected individuals from 10 Brazilian families with a positive Class III malocclusion segregation. Analysis of our data indicated that there was no evidence for linkage of any of the 6 microsatellite markers to a Class III locus at = zero, with data supporting exclusion for 5 of the 6 markers evaluated. The present work reinforces that Class III is likely to demonstrate locus heterogeneity, and there is a dependency of the genetic background of the population in linkage studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1544-0591
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1202-5
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Exclusion of Class III malocclusion candidate loci in Brazilian families.
pubmed:affiliation
Laboratório de Genética, Departamento de Genética e Morfologia, Campus Darcy Ribeiro, Universidade de Brasília, Asa Norte, CEP 70910900 Brasília, DF, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't