21806999

Source:http://linkedlifedata.com/resource/pubmed/id/21806999

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007634, umls-concept:C0013081, umls-concept:C0021758, umls-concept:C0074455, umls-concept:C0205263, umls-concept:C1819458
pubmed:issue	11-12
pubmed:dateCreated	2011-8-22
pubmed:abstractText	To investigate the effects of shikonin on phorbol myristate acetate (PMA) plus cyclic adenosine monophosphate (cAMP)-induced T helper (T(H)) 2 cell cytokine production, and the underlying mechanism.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0375521
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents..., http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal, http://linkedlifedata.com/resource/pubmed/chemical/GATA3 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/Gata3 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Kinase, http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Ikbkb protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5, http://linkedlifedata.com/resource/pubmed/chemical/Maf protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase..., http://linkedlifedata.com/resource/pubmed/chemical/Mitogens, http://linkedlifedata.com/resource/pubmed/chemical/Naphthoquinones, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-maf, http://linkedlifedata.com/resource/pubmed/chemical/shikonin
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	1879-0631
pubmed:author	pubmed-author:ChengYu-WenYW, pubmed-author:ChiangBor-LuenBL, pubmed-author:KangJaw-JouJJ, pubmed-author:LeeChen-ChenCC, pubmed-author:WangChien-NengCN
pubmed:copyrightInfo	Copyright © 2011 Elsevier Inc. All rights reserved.
pubmed:issnType	Electronic
pubmed:day	12
pubmed:volume	89
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	364-70
pubmed:meshHeading	pubmed-meshheading:21806999-Animals, pubmed-meshheading:21806999-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:21806999-Antineoplastic Agents, pubmed-meshheading:21806999-Cell Line, Tumor, pubmed-meshheading:21806999-Cytokines, pubmed-meshheading:21806999-Down-Regulation, pubmed-meshheading:21806999-Drugs, Chinese Herbal, pubmed-meshheading:21806999-GATA3 Transcription Factor, pubmed-meshheading:21806999-I-kappa B Kinase, pubmed-meshheading:21806999-I-kappa B Proteins, pubmed-meshheading:21806999-Interleukin-4, pubmed-meshheading:21806999-Interleukin-5, pubmed-meshheading:21806999-Mice, pubmed-meshheading:21806999-Mitogen-Activated Protein Kinase Kinases, pubmed-meshheading:21806999-Mitogens, pubmed-meshheading:21806999-Naphthoquinones, pubmed-meshheading:21806999-Proto-Oncogene Proteins c-maf, pubmed-meshheading:21806999-T-Lymphocytes
pubmed:year	2011
pubmed:articleTitle	Shikonin inhibited mitogen-activated IL-4 and IL-5 production on EL-4 cells through downregulation of GATA-3 and c-Maf induction.
pubmed:affiliation	Department of Microbiology and Immunology, School of Medicine, China Medical University, Taichung, Taiwan. leechenchen@mail.cmu.edu.tw
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't