| pubmed-article:2180400 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2180400 | lifeskim:mentions | umls-concept:C0006837 | lld:lifeskim |
| pubmed-article:2180400 | lifeskim:mentions | umls-concept:C0010798 | lld:lifeskim |
| pubmed-article:2180400 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:2180400 | lifeskim:mentions | umls-concept:C0003235 | lld:lifeskim |
| pubmed-article:2180400 | lifeskim:mentions | umls-concept:C0360363 | lld:lifeskim |
| pubmed-article:2180400 | lifeskim:mentions | umls-concept:C1417050 | lld:lifeskim |
| pubmed-article:2180400 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
| pubmed-article:2180400 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2180400 | pubmed:dateCreated | 1990-4-26 | lld:pubmed |
| pubmed-article:2180400 | pubmed:abstractText | The interaction of azole antifungal antibiotics with purified Candida albicans cytochrome P-450-dependent 14 alpha-sterol demethylase (P-450DM) was measured spectrophotometrically and by inhibition of enzyme activity. Ketoconazole and ICI 153066 (a triazole derivative) formed low-spin complexes with the ferric cytochrome and induced type II difference spectra. These spectra are indicative of an interaction between the azole moiety and the sixth co-ordination position of P-450DM haem. Both azoles inhibited the binding of CO to the sodium dithionite-reduced ferrous cytochrome, and inhibited reconstituted P-450DM activity by binding to the cytochrome with a one-to-one stoichiometry. Similarly, total inhibition of enzyme activity occurred when equimolar amounts of clotrimazole, miconazole or fluconazole were added to reconstituted P-450DM. These results correlated with the inhibition of P-450DM in broken cell preparations, confirming that all five azoles are potent inhibitors of ergosterol biosynthesis in C. albicans. | lld:pubmed |
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| pubmed-article:2180400 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2180400 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2180400 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2180400 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2180400 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:2180400 | pubmed:author | pubmed-author:BrownS BSB | lld:pubmed |
| pubmed-article:2180400 | pubmed:author | pubmed-author:AdamsD JDJ | lld:pubmed |
| pubmed-article:2180400 | pubmed:author | pubmed-author:DickinsonKK | lld:pubmed |
| pubmed-article:2180400 | pubmed:author | pubmed-author:EvansE GEG | lld:pubmed |
| pubmed-article:2180400 | pubmed:author | pubmed-author:HitchcockC... | lld:pubmed |
| pubmed-article:2180400 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2180400 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2180400 | pubmed:volume | 266 | lld:pubmed |
| pubmed-article:2180400 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2180400 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2180400 | pubmed:pagination | 475-80 | lld:pubmed |
| pubmed-article:2180400 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:2180400 | pubmed:meshHeading | pubmed-meshheading:2180400-... | lld:pubmed |
| pubmed-article:2180400 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2180400 | pubmed:articleTitle | Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14 alpha-sterol demethylase purified from Candida albicans. | lld:pubmed |
| pubmed-article:2180400 | pubmed:affiliation | Department of Microbiology, University of Leeds, U.K. | lld:pubmed |
| pubmed-article:2180400 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2180400 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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