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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-8-1
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pubmed:abstractText |
Cytoprotective growth factors such as vascular endothelial growth factor (VEGF) play important roles in myocardial protection from ischemia/reperfusion (I/R). Accumulating evidence suggests that the hypoxia-inducible factor 1 (HIF-1) pathway is a key regulator of VEGF production in the setting of I/R. The prolyl hydroxylase inhibitor mimosine can increase VEGF production through the HIF-1 pathway. We hypothesized that infusion of preischemic intracoronary mimosine would improve myocardial functional recovery after I/R.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1532-7361
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Mosby, Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-6
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pubmed:meshHeading |
pubmed-meshheading:21801958-Animals,
pubmed-meshheading:21801958-Coronary Vessels,
pubmed-meshheading:21801958-Enzyme Inhibitors,
pubmed-meshheading:21801958-Hypoxia-Inducible Factor 1,
pubmed-meshheading:21801958-Infusions, Intra-Arterial,
pubmed-meshheading:21801958-Male,
pubmed-meshheading:21801958-Mimosine,
pubmed-meshheading:21801958-Myocardial Ischemia,
pubmed-meshheading:21801958-Myocardial Reperfusion Injury,
pubmed-meshheading:21801958-Myocardium,
pubmed-meshheading:21801958-Rats,
pubmed-meshheading:21801958-Recovery of Function,
pubmed-meshheading:21801958-Signal Transduction,
pubmed-meshheading:21801958-Vascular Endothelial Growth Factor A
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pubmed:year |
2011
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pubmed:articleTitle |
Pretreatment with intracoronary mimosine improves postischemic myocardial functional recovery.
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pubmed:affiliation |
Department of Cardiovascular Surgery, Methodist Hospital, Indiana University School of Medicine, Indianapolis, IN, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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