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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-9-16
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pubmed:abstractText |
Telethonin (also known as titin-cap or t-cap) is a 19-kDa Z-disk protein with a unique ?-sheet structure, hypothesized to assemble in a palindromic way with the N-terminal portion of titin and to constitute a signalosome participating in the process of cardiomechanosensing. In addition, a variety of telethonin mutations are associated with the development of several different diseases; however, little is known about the underlying molecular mechanisms and telethonin's in vivo function.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4571
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pubmed:author |
pubmed-author:BartonPaul J RPJ,
pubmed-author:BirksEmma JEJ,
pubmed-author:BugMonikaM,
pubmed-author:BuyandelgerByambajavB,
pubmed-author:ChienKenneth RKR,
pubmed-author:DidiéMichaelM,
pubmed-author:DobbelsteinMatthiasM,
pubmed-author:FaulknerGeorgineG,
pubmed-author:FelkinLeanne ELE,
pubmed-author:FieldLoren JLJ,
pubmed-author:GranzierHenkH,
pubmed-author:GunkelSylviaS,
pubmed-author:HagnFranzF,
pubmed-author:KesslerHorstH,
pubmed-author:KnöllGudrunG,
pubmed-author:KnöllRalphR,
pubmed-author:KostinSawaS,
pubmed-author:KuChing-HsinCH,
pubmed-author:LangPatrickP,
pubmed-author:LinkeWolfgang AWA,
pubmed-author:MaierLars SLS,
pubmed-author:MiocicSnjezanaS,
pubmed-author:NeefStefanS,
pubmed-author:QuentinThomasT,
pubmed-author:SattlerMichaelM,
pubmed-author:SchäferKatrinK,
pubmed-author:SchmidtAlbrechtA,
pubmed-author:TeucherNilsN,
pubmed-author:ToischerKarlK,
pubmed-author:UnsöldBernhardB,
pubmed-author:WesselsJohannesJ,
pubmed-author:WilmannsMatthiasM,
pubmed-author:ZimmermannWolfram-HubertusWH,
pubmed-author:ZouPeijianP
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
758-69
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pubmed:meshHeading |
pubmed-meshheading:21799151-Adaptation, Physiological,
pubmed-meshheading:21799151-Animals,
pubmed-meshheading:21799151-Animals, Genetically Modified,
pubmed-meshheading:21799151-Apoptosis,
pubmed-meshheading:21799151-Biomechanics,
pubmed-meshheading:21799151-Cell Line, Tumor,
pubmed-meshheading:21799151-Disease Models, Animal,
pubmed-meshheading:21799151-Echocardiography,
pubmed-meshheading:21799151-Fibrosis,
pubmed-meshheading:21799151-Genotype,
pubmed-meshheading:21799151-Heart,
pubmed-meshheading:21799151-Heart Failure,
pubmed-meshheading:21799151-Humans,
pubmed-meshheading:21799151-Mechanotransduction, Cellular,
pubmed-meshheading:21799151-Mice,
pubmed-meshheading:21799151-Mice, Knockout,
pubmed-meshheading:21799151-Muscle Proteins,
pubmed-meshheading:21799151-Myocardium,
pubmed-meshheading:21799151-Phenotype,
pubmed-meshheading:21799151-RNA Interference,
pubmed-meshheading:21799151-Rats,
pubmed-meshheading:21799151-Sarcomeres,
pubmed-meshheading:21799151-Stress, Mechanical,
pubmed-meshheading:21799151-Transfection,
pubmed-meshheading:21799151-Tumor Suppressor Protein p53
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pubmed:year |
2011
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pubmed:articleTitle |
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.
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pubmed:affiliation |
Imperial College, National Heart & Lung Institute, British Heart Foundation, Centre for Research Excellence, Myocardial Genetics, London, UK. r.knoell@imperial.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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