Linked Life Data

21798241

Source:http://linkedlifedata.com/resource/pubmed/id/21798241

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-8-15
pubmed:abstractText
Nuclear factor ?B (NF-?B) is a transcription factor that regulates a set of genes that are critical to many biological phenomena, including liver tumorigenesis. To identify microRNAs (miRNAs) that regulate NF-?B activity in the liver, we screened 60 miRNAs expressed in hepatocytes for their ability to modulate NF-?B activity. We found that miRNA-22 and miRNA-140-3p significantly suppressed NF-?B activity by regulating the expression of nuclear receptor coactivator 1 (NCOA1) and nuclear receptor-interacting protein 1 (NRIP1), both of which are NF-?B coactivators. Our results provide new information about the roles of miRNAs in the regulation of NF-?B activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1090-2104
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
12
pubmed:volume
411
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
826-31
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
MicroRNA-22 and microRNA-140 suppress NF-?B activity by regulating the expression of NF-?B coactivators.
pubmed:affiliation
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't