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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-7-27
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pubmed:abstractText |
Population sequencing was performed for persons identified with persistent low-level viremia in 2 clinical trials. Persistent low-level viremia (defined as plasma HIV-1 RNA level >50 and <1000 copies/mL in at least 2 determinations over a 24-week period, after at least 24 weeks of antiretroviral therapy) was observed in 65 (5.6%) of 1158 patients at risk. New resistance mutations were detected during persistent low-level viremia in 37% of the 54 evaluable cases. The most common mutations were M184I/V (14 cases), K103N (9), and M230L (3). Detection of new mutations was associated with higher HIV-1 RNA levels during persistent low-level viremia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1537-6613
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
204
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
515-20
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pubmed:dateRevised |
2011-10-28
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pubmed:meshHeading |
pubmed-meshheading:21791652-Adult,
pubmed-meshheading:21791652-Drug Resistance, Viral,
pubmed-meshheading:21791652-Female,
pubmed-meshheading:21791652-HIV Infections,
pubmed-meshheading:21791652-HIV-1,
pubmed-meshheading:21791652-Humans,
pubmed-meshheading:21791652-Male,
pubmed-meshheading:21791652-Mutation,
pubmed-meshheading:21791652-Retrospective Studies,
pubmed-meshheading:21791652-Viremia
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pubmed:year |
2011
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pubmed:articleTitle |
Antiretroviral drug resistance in HIV-1-infected patients experiencing persistent low-level viremia during first-line therapy.
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pubmed:affiliation |
Division of Infectious Diseases, Northwestern University, Chicago, Illinois 60611, USA. b-taiwo@northwestern.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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